Dihydroartemisinin-piperaquine versus chloroquine for the treatment of uncomplicated Plasmodium vivax malaria with concurrent or delayed high-dose primaquine in Brazil (Curavivax): an open-label, single-centre, randomised clinical trial.
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| Title: | Dihydroartemisinin-piperaquine versus chloroquine for the treatment of uncomplicated Plasmodium vivax malaria with concurrent or delayed high-dose primaquine in Brazil (Curavivax): an open-label, single-centre, randomised clinical trial. |
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| Authors: | Baía-da-Silva DC; Instituto Leônidas and Maria Deane, Fiocruz, Manaus, Brazil; Universidade Nilton Lins, Manaus, Brazil., Machado KVA; Universidade Nilton Lins, Manaus, Brazil; Universidade Federal do Amazonas, Manaus, Brazil., Rabelo ALR; Universidade Nilton Lins, Manaus, Brazil; Universidade Federal do Amazonas, Manaus, Brazil., da Silva Balieiro AA; Instituto Leônidas and Maria Deane, Fiocruz, Manaus, Brazil., Barbosa ASL; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Costa MRF; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Sampaio VS; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil; Instituto Todos pela Saúde, São Paulo, Brazil., Melo GC; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil., Alexandre MAA; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil., Alencar ACC; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Nascimento CT; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Jerônimo CMP; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil., Marcovski MS; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Barbosa LRA; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil., Valle CS; Vice-Presidência de Pesquisa e Coleções Biológicas, Plataforma de Pesquisa Clínica, Fiocruz, Rio de Janeiro, Brazil., Carrilho TAA; Vice-Presidência de Pesquisa e Coleções Biológicas, Plataforma de Pesquisa Clínica, Fiocruz, Rio de Janeiro, Brazil., Vieira JLF; Universidade Federal do Pará, Belém, Brazil., de Melo MM; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil., Dinelly KMO; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil., Omena AG; Instituto Leônidas and Maria Deane, Fiocruz, Manaus, Brazil; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Brito-Sousa JD; Instituto Leônidas and Maria Deane, Fiocruz, Manaus, Brazil; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Barreiros GA; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Rocha YV; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Filho ACA; Universidade Federal do Amazonas, Manaus, Brazil; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil., Bassat Q; Barcelona Institute for Global Health, Barcelona, Spain; Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique; Institución Catalana de Investigación y Estudios Avanzados, Barcelona, Spain; Institut Clínic de Medicina I Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain; Pediatrics Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain., Alecrim MDGC; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil., Siqueira AM; Laboratório de Doenças Febris Agudas, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil., Lacerda MVG; Instituto Leônidas and Maria Deane, Fiocruz, Manaus, Brazil; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: marcuslacerda.br@gmail.com. |
| Source: | The Lancet. Infectious diseases [Lancet Infect Dis] 2026 May 11. Date of Electronic Publication: 2026 May 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42114535 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dihydroartemisinin-piperaquine versus chloroquine for the treatment of uncomplicated Plasmodium vivax malaria with concurrent or delayed high-dose primaquine in Brazil (Curavivax): an open-label, single-centre, randomised clinical trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Baía-da-Silva+DC%22">Baía-da-Silva DC</searchLink>; Instituto Leônidas and Maria Deane, Fiocruz, Manaus, Brazil; Universidade Nilton Lins, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Machado+KVA%22">Machado KVA</searchLink>; Universidade Nilton Lins, Manaus, Brazil; Universidade Federal do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Rabelo+ALR%22">Rabelo ALR</searchLink>; Universidade Nilton Lins, Manaus, Brazil; Universidade Federal do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Balieiro+AA%22">da Silva Balieiro AA</searchLink>; Instituto Leônidas and Maria Deane, Fiocruz, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Barbosa+ASL%22">Barbosa ASL</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Costa+MRF%22">Costa MRF</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Sampaio+VS%22">Sampaio VS</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil; Instituto Todos pela Saúde, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Melo+GC%22">Melo GC</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Alexandre+MAA%22">Alexandre MAA</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Alencar+ACC%22">Alencar ACC</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Nascimento+CT%22">Nascimento CT</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Jerônimo+CMP%22">Jerônimo CMP</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Marcovski+MS%22">Marcovski MS</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Barbosa+LRA%22">Barbosa LRA</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Valle+CS%22">Valle CS</searchLink>; Vice-Presidência de Pesquisa e Coleções Biológicas, Plataforma de Pesquisa Clínica, Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Carrilho+TAA%22">Carrilho TAA</searchLink>; Vice-Presidência de Pesquisa e Coleções Biológicas, Plataforma de Pesquisa Clínica, Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Vieira+JLF%22">Vieira JLF</searchLink>; Universidade Federal do Pará, Belém, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Melo+MM%22">de Melo MM</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Dinelly+KMO%22">Dinelly KMO</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Omena+AG%22">Omena AG</searchLink>; Instituto Leônidas and Maria Deane, Fiocruz, Manaus, Brazil; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Brito-Sousa+JD%22">Brito-Sousa JD</searchLink>; Instituto Leônidas and Maria Deane, Fiocruz, Manaus, Brazil; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Barreiros+GA%22">Barreiros GA</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Rocha+YV%22">Rocha YV</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Filho+ACA%22">Filho ACA</searchLink>; Universidade Federal do Amazonas, Manaus, Brazil; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Bassat+Q%22">Bassat Q</searchLink>; Barcelona Institute for Global Health, Barcelona, Spain; Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique; Institución Catalana de Investigación y Estudios Avanzados, Barcelona, Spain; Institut Clínic de Medicina I Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain; Pediatrics Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Esplugues, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alecrim+MDGC%22">Alecrim MDGC</searchLink>; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil.<br /><searchLink fieldCode="AU" term="%22Siqueira+AM%22">Siqueira AM</searchLink>; Laboratório de Doenças Febris Agudas, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Lacerda+MVG%22">Lacerda MVG</searchLink>; Instituto Leônidas and Maria Deane, Fiocruz, Manaus, Brazil; Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Universidade do Estado do Amazonas, Manaus, Brazil; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: marcuslacerda.br@gmail.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101130150%22">The Lancet. Infectious diseases</searchLink> [Lancet Infect Dis] 2026 May 11. <i>Date of Electronic Publication: </i>2026 May 11. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101130150 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-4457 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214733099%22">14733099 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Infect Dis <i>Subsets: </i>MEDLINE |
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