All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer.

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Title: All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer.
Authors: Li CF; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. cli14@mdanderson.org.; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. cli14@mdanderson.org., Wei Y; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lee HH; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chang WC; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan., Xiong Y; Proteomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tang Y; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yang R; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The AHMC Dermatology and Research Center, Arcadia, CA, USA., Yao J; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang H; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang X; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu M; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Park J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fu J; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang YN; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bai LY; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, and China Medical University, Taichung, Taiwan., Wang SC; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, College of Medicine, and Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan., Chou CW; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Graduate Institute of Biomedical Sciences, College of Medicine, and Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.; Division of Hematology/Medical Oncology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Ling J; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chu YY; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Xun Z; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liang H; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Maitra A; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yao W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA., Yu D; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA., Chiao PJ; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA., Ying H; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. HYing@mdanderson.org.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. HYing@mdanderson.org., Hung MC; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. mhung@cmu.edu.tw.; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, and China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.; Graduate Institute of Biomedical Sciences, College of Medicine, and Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.
Source: Nature communications [Nat Commun] 2026 May 11. Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72271-5