Real-world effectiveness, safety and patient-reported outcomes of sarilumab in patients with rheumatoid arthritis: a 52-week, prospective, open-label, non-interventional, observational, nationwide, large-cohort study in Japan (PROFILE-J).

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Title: Real-world effectiveness, safety and patient-reported outcomes of sarilumab in patients with rheumatoid arthritis: a 52-week, prospective, open-label, non-interventional, observational, nationwide, large-cohort study in Japan (PROFILE-J).
Authors: Tanaka Y; Department of Molecular Targeted Therapeutics, University of Occupational and Environmental Health, Kitakyushu, Japan tanaka@med.uoeh-u.ac.jp., Hanami K; The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Miyazaki Y; The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Ishigatsubo Y; Yokohama Rheumatology Clinic, Yokohama, Japan., Iwamoto T; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Ushio K; Rheumatology, Ushio Clinic, Osaka, Japan., Okano Y; Division of Rheumatology, Department of Medicine, National Hospital Organisation Tokyo Medical Center, Meguro, Japan., Onobori M; Rheumatology, Onobori Clinic, Tsukuba, Japan., Kawahata K; Department of Rheumatology and Allergology, St Marianna University School of Medicine, Kawasaki, Japan., Saegusa J; Department of Rheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan., Nakamura Y; Orthopedic Surgery, Showa Inan General Hospital, Komagane, Japan., Natsumeda M; Rheumatic Disease Center, Mabi Memorial Hospital, Kurashiki, Japan., Nozaki Y; Department of Hematology and Rheumatology, Kindai University Faculty of Medicine Graduate School of Medical Sciences, Osakasayama, Japan., Miyamoto T; Department of Rheumatology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan., Yamanishi Y; Rheumatology, Hiroshima Rheumatology Clinic, Hiroshima, Japan., Ishiguro N; Aichi Developmental Disability Center, Kasugai, Japan., Kumanogoh A; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan., Takeuchi T; Saitama Medical University, Iruma, Japan.; Keio University School of Medicine, Shinjuku, Japan., Tohma S; National Hospital Organisation Tokyo National Hospital, Kiyose, Japan., Fujino Y; Department of Environmental Epidemiology, University of Occupational and Environmental Health, Kitakyushu, Japan., Kameda H; Division of Rheumatology, Faculty of Medicine, Toho University, Meguro, Japan.
Source: RMD open [RMD Open] 2026 May 12; Vol. 12 (2). Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article; Observational Study; Multicenter Study
Journal Info: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101662038 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-5933 (Electronic) Linking ISSN: 20565933 NLM ISO Abbreviation: RMD Open Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2056-5933
DOI:10.1136/rmdopen-2025-006446