Heterogeneous endocrine cell composition defines human islet functional phenotypes.
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| Title: | Heterogeneous endocrine cell composition defines human islet functional phenotypes. |
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| Authors: | Evans-Molina C; Departments of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; The Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; The Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA. cevansmo@iu.edu., Pettway YD; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Saunders DC; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sharp SA; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA., Bate TS; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sun H; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA., Durai H; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Mei S; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Coldren A; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Davis C; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Reihsmann CV; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hopkirk AL; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Taylor J; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Bradley A; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Aramandla R; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Poffenberger G; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Eskaros A; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jenkins R; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Shi D; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Xu K; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Kang H; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Rajesh V; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA., Thaman S; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA., Feng F; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cartailler JP; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA., Powers AC; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; VA Tennessee Valley Healthcare System, Nashville, TN, USA., Abraham K; Division of Diabetes, Endocrinology, & Metabolic Diseases, National Institutes of Health, Bethesda, MD, USA., Gloyn AL; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu.; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu.; Stanford Diabetes Center, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu., Niland JC; Department of Diabetes and Cancer Discovery Science, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA. jniland@coh.org., Brissova M; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. marcela.brissova@vanderbilt.edu. |
| Corporate Authors: | IIDP Consortium |
| Source: | Nature communications [Nat Commun] 2026 May 12; Vol. 17 (1). Date of Electronic Publication: 2026 May 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-70689-5 |
