View in EDS HTML Full Text PDF Full Text

Heterogeneous endocrine cell composition defines human islet functional phenotypes.

Saved in:
Bibliographic Details
Title: Heterogeneous endocrine cell composition defines human islet functional phenotypes.
Authors: Evans-Molina C; Departments of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; The Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; The Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA. cevansmo@iu.edu., Pettway YD; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Saunders DC; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sharp SA; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA., Bate TS; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sun H; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA., Durai H; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Mei S; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Coldren A; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Davis C; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Reihsmann CV; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Hopkirk AL; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Taylor J; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Bradley A; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Aramandla R; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Poffenberger G; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Eskaros A; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jenkins R; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Shi D; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Xu K; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Kang H; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Rajesh V; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA., Thaman S; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA., Feng F; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cartailler JP; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA., Powers AC; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; VA Tennessee Valley Healthcare System, Nashville, TN, USA., Abraham K; Division of Diabetes, Endocrinology, & Metabolic Diseases, National Institutes of Health, Bethesda, MD, USA., Gloyn AL; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu.; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu.; Stanford Diabetes Center, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu., Niland JC; Department of Diabetes and Cancer Discovery Science, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA. jniland@coh.org., Brissova M; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. marcela.brissova@vanderbilt.edu.
Corporate Authors: IIDP Consortium
Source: Nature communications [Nat Commun] 2026 May 12; Vol. 17 (1). Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42120367
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Heterogeneous endocrine cell composition defines human islet functional phenotypes.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Evans-Molina+C%22">Evans-Molina C</searchLink>; Departments of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; The Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; The Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA. cevansmo@iu.edu.<br /><searchLink fieldCode="AU" term="%22Pettway+YD%22">Pettway YD</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Saunders+DC%22">Saunders DC</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+SA%22">Sharp SA</searchLink>; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bate+TS%22">Bate TS</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sun+H%22">Sun H</searchLink>; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Durai+H%22">Durai H</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Mei+S%22">Mei S</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Coldren+A%22">Coldren A</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Davis+C%22">Davis C</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Reihsmann+CV%22">Reihsmann CV</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Hopkirk+AL%22">Hopkirk AL</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+J%22">Taylor J</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bradley+A%22">Bradley A</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Aramandla+R%22">Aramandla R</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Poffenberger+G%22">Poffenberger G</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Eskaros+A%22">Eskaros A</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Jenkins+R%22">Jenkins R</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Shi+D%22">Shi D</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Xu+K%22">Xu K</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kang+H%22">Kang H</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rajesh+V%22">Rajesh V</searchLink>; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Thaman+S%22">Thaman S</searchLink>; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Feng+F%22">Feng F</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cartailler+JP%22">Cartailler JP</searchLink>; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Powers+AC%22">Powers AC</searchLink>; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; VA Tennessee Valley Healthcare System, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Abraham+K%22">Abraham K</searchLink>; Division of Diabetes, Endocrinology, & Metabolic Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gloyn+AL%22">Gloyn AL</searchLink>; Department of Pediatrics, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu.; Department of Genetics, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu.; Stanford Diabetes Center, Stanford School of Medicine, Stanford, CA, USA. agloyn@stanford.edu.<br /><searchLink fieldCode="AU" term="%22Niland+JC%22">Niland JC</searchLink>; Department of Diabetes and Cancer Discovery Science, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA. jniland@coh.org.<br /><searchLink fieldCode="AU" term="%22Brissova+M%22">Brissova M</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. marcela.brissova@vanderbilt.edu.
– Name: AuthorCorporate
  Label: Corporate Authors
  Group: Au
  Data: <searchLink fieldCode="CA" term="%22IIDP+Consortium%22">IIDP Consortium</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 May 12; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 12.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42120367
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-026-70689-5
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Heterogeneous endocrine cell composition defines human islet functional phenotypes.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Evans-Molina C
      – PersonEntity:
          Name:
            NameFull: Pettway YD
      – PersonEntity:
          Name:
            NameFull: Saunders DC
      – PersonEntity:
          Name:
            NameFull: Sharp SA
      – PersonEntity:
          Name:
            NameFull: Bate TS
      – PersonEntity:
          Name:
            NameFull: Sun H
      – PersonEntity:
          Name:
            NameFull: Durai H
      – PersonEntity:
          Name:
            NameFull: Mei S
      – PersonEntity:
          Name:
            NameFull: Coldren A
      – PersonEntity:
          Name:
            NameFull: Davis C
      – PersonEntity:
          Name:
            NameFull: Reihsmann CV
      – PersonEntity:
          Name:
            NameFull: Hopkirk AL
      – PersonEntity:
          Name:
            NameFull: Taylor J
      – PersonEntity:
          Name:
            NameFull: Bradley A
      – PersonEntity:
          Name:
            NameFull: Aramandla R
      – PersonEntity:
          Name:
            NameFull: Poffenberger G
      – PersonEntity:
          Name:
            NameFull: Eskaros A
      – PersonEntity:
          Name:
            NameFull: Jenkins R
      – PersonEntity:
          Name:
            NameFull: Shi D
      – PersonEntity:
          Name:
            NameFull: Xu K
      – PersonEntity:
          Name:
            NameFull: Kang H
      – PersonEntity:
          Name:
            NameFull: Rajesh V
      – PersonEntity:
          Name:
            NameFull: Thaman S
      – PersonEntity:
          Name:
            NameFull: Feng F
      – PersonEntity:
          Name:
            NameFull: Cartailler JP
      – PersonEntity:
          Name:
            NameFull: Powers AC
      – PersonEntity:
          Name:
            NameFull: Abraham K
      – PersonEntity:
          Name:
            NameFull: Gloyn AL
      – PersonEntity:
          Name:
            NameFull: Niland JC
      – PersonEntity:
          Name:
            NameFull: Brissova M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 12
              M: 05
              Text: 2026 May 12
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1