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Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan.

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Title: Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan.
Authors: Yang C; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Xu Z; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., He ST; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Zheng GJ; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Wang JX; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Zang FZ; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Hu JQ; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Wang YH; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Zhang WY; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Gao CF; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Zhang TH; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Ye Y; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Chen H; Medical College, Yangzhou University, Yangzhou, China., Kong FQ; Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China., Lv X; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Liang L; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Sun YL; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Wang ZW; Department of Orthopedics, No. 905 Hospital, Naval Medical University, Shanghai, China., Wang ZX; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Cao P; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China., Wu XD; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China. wxdstonecold@163.com., Gao B; Department of Orthopedics, Xijing Hospital, Air Force Medical University, Xi'an, China. gaobofmmu@hotmail.com., Tian Y; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China. hrs918@163.com., Hu B; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China. bhu15@smmu.edu.cn., Chen HJ; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China. dr_chj@smmu.edu.cn.
Source: Nature aging [Nat Aging] 2026 May; Vol. 6 (5), pp. 1021-1041. Date of Electronic Publication: 2026 May 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan.
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  Data: <searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22He+ST%22">He ST</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zheng+GJ%22">Zheng GJ</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+JX%22">Wang JX</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zang+FZ%22">Zang FZ</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Hu+JQ%22">Hu JQ</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+YH%22">Wang YH</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+WY%22">Zhang WY</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Gao+CF%22">Gao CF</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+TH%22">Zhang TH</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ye+Y%22">Ye Y</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Medical College, Yangzhou University, Yangzhou, China.<br /><searchLink fieldCode="AU" term="%22Kong+FQ%22">Kong FQ</searchLink>; Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Lv+X%22">Lv X</searchLink>; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Liang+L%22">Liang L</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Sun+YL%22">Sun YL</searchLink>; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+ZW%22">Wang ZW</searchLink>; Department of Orthopedics, No. 905 Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+ZX%22">Wang ZX</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Cao+P%22">Cao P</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wu+XD%22">Wu XD</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China. wxdstonecold@163.com.<br /><searchLink fieldCode="AU" term="%22Gao+B%22">Gao B</searchLink>; Department of Orthopedics, Xijing Hospital, Air Force Medical University, Xi'an, China. gaobofmmu@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China. hrs918@163.com.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China. bhu15@smmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+HJ%22">Chen HJ</searchLink>; Department of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China. dr_chj@smmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2026 May; Vol. 6 (5), pp. 1021-1041. <i>Date of Electronic Publication: </i>2026 May 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+US%22">Nature Publishing Group US </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101773306 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-8465 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226628465%22">26628465 </searchLink><i>NLM ISO Abbreviation: </i>Nat Aging <i>Subsets: </i>MEDLINE
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