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Contribution of Risk Factors, Including Polygenic Score, to the Multifactorial Risk Assessment for the Implementation of Personalized Breast Cancer Screening: Insights from the PERSPECTIVE: Integration and Implementation Project.

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Title: Contribution of Risk Factors, Including Polygenic Score, to the Multifactorial Risk Assessment for the Implementation of Personalized Breast Cancer Screening: Insights from the PERSPECTIVE: Integration and Implementation Project.
Authors: Yang X; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK., Usher-Smith JA; Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK., Blackmore KM; Ontario Health, Toronto, ON M5G 2L3, Canada., Brooks JD; Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada., Bell KA; Ontario Health, Toronto, ON M5G 2L3, Canada., Carver T; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK., Chang A; Ontario Health, Toronto, ON M5G 2L3, Canada., Chiquette J; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.; Department of Family Medicine and Emergency Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK., Eisen A; Ontario Health, Toronto, ON M5G 2L3, Canada.; Sunnybrook Health Science Centre, Toronto, ON M4N 3M5, Canada.; Department of Oncology, McMaster University, Hamilton, ON L8V 5C2, Canada., Eloy L; Programme Québécois de Cancérologie, Ministère de la Santé et des Services Sociaux, Quebec City, QC G1S 2M1, Canada.; Centre Intégré de Santé et de Services Sociaux de Lanaudière, Centre hospitalier de Lanaudière, Saint-Charles Borromée, QC J6E 6J2, Canada., Fienberg S; Ontario Health, Toronto, ON M5G 2L3, Canada., Joly Y; Centre of Genomics and Policy, McGill University, Montreal, QC H3A 0G1, Canada., Kim RH; Ontario Health, Toronto, ON M5G 2L3, Canada.; Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada., Knoppers BM; Centre of Genomics and Policy, McGill University, Montreal, QC H3A 0G1, Canada., Lambert-Côté L; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada., Nabi H; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.; Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada.; Université Laval Cancer Research Center, Quebec City, QC G1R 3S3, Canada., Pashayan N; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK., Soucy P; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada., Stockley TL; Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.; Division of Clinical Laboratory Genetics, University Health Network, Toronto, ON M5G 2C4, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Turgeon A; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada., Walker MJ; Ontario Health, Toronto, ON M5G 2L3, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada., Wolfson M; School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1G 5Z3, Canada., Dorval M; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.; Université Laval Cancer Research Center, Quebec City, QC G1R 3S3, Canada.; Faculty of Pharmacy, Université Laval, Quebec City, QC G1V 0A6, Canada., Chiarelli AM; Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada., Antoniou AC; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK., Simard J; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.; Université Laval Cancer Research Center, Quebec City, QC G1R 3S3, Canada.; Department of Molecular Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 4G2, Canada.
Source: Cancers [Cancers (Basel)] 2026 May 05; Vol. 18 (9). Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Contribution of Risk Factors, Including Polygenic Score, to the Multifactorial Risk Assessment for the Implementation of Personalized Breast Cancer Screening: Insights from the PERSPECTIVE: Integration and Implementation Project.
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  Data: <searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Usher-Smith+JA%22">Usher-Smith JA</searchLink>; Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Blackmore+KM%22">Blackmore KM</searchLink>; Ontario Health, Toronto, ON M5G 2L3, Canada.<br /><searchLink fieldCode="AU" term="%22Brooks+JD%22">Brooks JD</searchLink>; Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada.<br /><searchLink fieldCode="AU" term="%22Bell+KA%22">Bell KA</searchLink>; Ontario Health, Toronto, ON M5G 2L3, Canada.<br /><searchLink fieldCode="AU" term="%22Carver+T%22">Carver T</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Chang+A%22">Chang A</searchLink>; Ontario Health, Toronto, ON M5G 2L3, Canada.<br /><searchLink fieldCode="AU" term="%22Chiquette+J%22">Chiquette J</searchLink>; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.; Department of Family Medicine and Emergency Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada.<br /><searchLink fieldCode="AU" term="%22Easton+DF%22">Easton DF</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Eisen+A%22">Eisen A</searchLink>; Ontario Health, Toronto, ON M5G 2L3, Canada.; Sunnybrook Health Science Centre, Toronto, ON M4N 3M5, Canada.; Department of Oncology, McMaster University, Hamilton, ON L8V 5C2, Canada.<br /><searchLink fieldCode="AU" term="%22Eloy+L%22">Eloy L</searchLink>; Programme Québécois de Cancérologie, Ministère de la Santé et des Services Sociaux, Quebec City, QC G1S 2M1, Canada.; Centre Intégré de Santé et de Services Sociaux de Lanaudière, Centre hospitalier de Lanaudière, Saint-Charles Borromée, QC J6E 6J2, Canada.<br /><searchLink fieldCode="AU" term="%22Fienberg+S%22">Fienberg S</searchLink>; Ontario Health, Toronto, ON M5G 2L3, Canada.<br /><searchLink fieldCode="AU" term="%22Joly+Y%22">Joly Y</searchLink>; Centre of Genomics and Policy, McGill University, Montreal, QC H3A 0G1, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+RH%22">Kim RH</searchLink>; Ontario Health, Toronto, ON M5G 2L3, Canada.; Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.<br /><searchLink fieldCode="AU" term="%22Knoppers+BM%22">Knoppers BM</searchLink>; Centre of Genomics and Policy, McGill University, Montreal, QC H3A 0G1, Canada.<br /><searchLink fieldCode="AU" term="%22Lambert-Côté+L%22">Lambert-Côté L</searchLink>; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.<br /><searchLink fieldCode="AU" term="%22Nabi+H%22">Nabi H</searchLink>; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.; Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada.; Université Laval Cancer Research Center, Quebec City, QC G1R 3S3, Canada.<br /><searchLink fieldCode="AU" term="%22Pashayan+N%22">Pashayan N</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Soucy+P%22">Soucy P</searchLink>; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.<br /><searchLink fieldCode="AU" term="%22Stockley+TL%22">Stockley TL</searchLink>; Princess Margaret Cancer Centre, Toronto, ON M5G 2M9, Canada.; Division of Clinical Laboratory Genetics, University Health Network, Toronto, ON M5G 2C4, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Turgeon+A%22">Turgeon A</searchLink>; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.<br /><searchLink fieldCode="AU" term="%22Walker+MJ%22">Walker MJ</searchLink>; Ontario Health, Toronto, ON M5G 2L3, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada.<br /><searchLink fieldCode="AU" term="%22Wolfson+M%22">Wolfson M</searchLink>; School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON K1G 5Z3, Canada.<br /><searchLink fieldCode="AU" term="%22Dorval+M%22">Dorval M</searchLink>; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.; Université Laval Cancer Research Center, Quebec City, QC G1R 3S3, Canada.; Faculty of Pharmacy, Université Laval, Quebec City, QC G1V 0A6, Canada.<br /><searchLink fieldCode="AU" term="%22Chiarelli+AM%22">Chiarelli AM</searchLink>; Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada.<br /><searchLink fieldCode="AU" term="%22Antoniou+AC%22">Antoniou AC</searchLink>; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.<br /><searchLink fieldCode="AU" term="%22Simard+J%22">Simard J</searchLink>; CHU de Québec-Université Laval Research Center, Quebec City, QC G1V 4G2, Canada.; Université Laval Cancer Research Center, Quebec City, QC G1R 3S3, Canada.; Department of Molecular Medicine, Faculty of Medicine, Université Laval, Quebec City, QC G1V 4G2, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101526829%22">Cancers</searchLink> [Cancers (Basel)] 2026 May 05; Vol. 18 (9). <i>Date of Electronic Publication: </i>2026 May 05.
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