Safety and pharmacokinetics of GSK3494245, a highly selective Leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: A Phase 1, randomized, single ascending dose escalation study in healthy participants.
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| Title: | Safety and pharmacokinetics of GSK3494245, a highly selective Leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: A Phase 1, randomized, single ascending dose escalation study in healthy participants. |
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| Authors: | Moodley M; Global Health Medicines R&D, GSK, London, United Kingdom., Kostapanos M; GSK Clinical Unit Cambridge, GSK, Cambridge, United Kingdom.; Department of Medicine, Addenbrooke's Hospital, Cambridge University Hospitals and University of Cambridge, Cambridge, United Kingdom., Iavarone L; Clinical Pharmacology, Modeling and Simulation, Parexel, Milan, Italy., Bracher M; Global Health, GSK, Stevenage, Hertfordshire, United Kingdom., Lavezzi SM; Clinical Pharmacology, Modeling and Simulation, Parexel, Dublin, Ireland., Davy M; Global Health, GSK, Stevenage, Hertfordshire, United Kingdom., Singh P; Global Safety, GSK, Bangalore, Karnataka, India., Bhat R; Biostatistics, GSK, Bangalore, Karnataka, India., Wong D; Global Clinical Delivery, R&D, GSK, Stevenage, Hertfordshire, United Kingdom., Sharma H; Vaccines Clinical Sciences, GSK, London, United Kingdom., Tan LK; Clinical Development, ViiV Healthcare Ltd., London, United Kingdom., Miles TJ; Global Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain. |
| Source: | PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2026 May 13; Vol. 20 (5), pp. e0014181. Date of Electronic Publication: 2026 May 13 (Print Publication: 2026). |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1935-2735 |
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| DOI: | 10.1371/journal.pntd.0014181 |
