Organoid models reveal mechanistic connections and sirolimus efficacy in liver-vascular steatosis and foam cell formation.

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Title: Organoid models reveal mechanistic connections and sirolimus efficacy in liver-vascular steatosis and foam cell formation.
Authors: Kota VG; NUS Biomedical Engineering, College of Design and Engineering, National University of Singapore, 4 Engineering Drive 3 Block 4, #04-08, 117583, Singapore. Electronic address: e1100036@u.nus.edu., Yi JLJ; NUS Biomedical Engineering, College of Design and Engineering, National University of Singapore, 4 Engineering Drive 3 Block 4, #04-08, 117583, Singapore., Zhang Z; Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore, 117593, Singapore., Yooyuen A; NUS Biomedical Engineering, College of Design and Engineering, National University of Singapore, 4 Engineering Drive 3 Block 4, #04-08, 117583, Singapore., Yu H; Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore, 117593, Singapore; Mechanobiology Institute, National University of Singapore, T-Lab, #05-01, 5A Engineering Drive 1, Singapore, 117411, Singapore; CAMP, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, Level 4 Enterprise Wing, Singapore, 138602, Singapore., Leo HL; NUS Biomedical Engineering, College of Design and Engineering, National University of Singapore, 4 Engineering Drive 3 Block 4, #04-08, 117583, Singapore.
Source: Atherosclerosis [Atherosclerosis] 2026 Jun; Vol. 417, pp. 120762. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Organoid models reveal mechanistic connections and sirolimus efficacy in liver-vascular steatosis and foam cell formation.
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  Data: <searchLink fieldCode="AU" term="%22Kota+VG%22">Kota VG</searchLink>; NUS Biomedical Engineering, College of Design and Engineering, National University of Singapore, 4 Engineering Drive 3 Block 4, #04-08, 117583, Singapore. Electronic address: e1100036@u.nus.edu.<br /><searchLink fieldCode="AU" term="%22Yi+JLJ%22">Yi JLJ</searchLink>; NUS Biomedical Engineering, College of Design and Engineering, National University of Singapore, 4 Engineering Drive 3 Block 4, #04-08, 117583, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore, 117593, Singapore.<br /><searchLink fieldCode="AU" term="%22Yooyuen+A%22">Yooyuen A</searchLink>; NUS Biomedical Engineering, College of Design and Engineering, National University of Singapore, 4 Engineering Drive 3 Block 4, #04-08, 117583, Singapore.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore, 117593, Singapore; Mechanobiology Institute, National University of Singapore, T-Lab, #05-01, 5A Engineering Drive 1, Singapore, 117411, Singapore; CAMP, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, Level 4 Enterprise Wing, Singapore, 138602, Singapore.<br /><searchLink fieldCode="AU" term="%22Leo+HL%22">Leo HL</searchLink>; NUS Biomedical Engineering, College of Design and Engineering, National University of Singapore, 4 Engineering Drive 3 Block 4, #04-08, 117583, Singapore.
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  Data: <searchLink fieldCode="JN" term="%220242543%22">Atherosclerosis</searchLink> [Atherosclerosis] 2026 Jun; Vol. 417, pp. 120762. <i>Date of Electronic Publication: </i>2026 May 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>0242543 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-1484 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219150%22">00219150 </searchLink><i>NLM ISO Abbreviation: </i>Atherosclerosis <i>Subsets: </i>MEDLINE
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.atherosclerosis.2026.120762
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      – Code: eng
        Text: English
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        StartPage: 120762
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      – TitleFull: Organoid models reveal mechanistic connections and sirolimus efficacy in liver-vascular steatosis and foam cell formation.
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            NameFull: Yi JLJ
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            – D: 01
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              Text: 2026 Jun
              Type: published
              Y: 2026
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              Value: 1879-1484
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              Value: 417
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            – TitleFull: Atherosclerosis
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