Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors.
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| Title: | Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors. |
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| Authors: | Klink N; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.; Max Planck Institute of Molecular Physiology, Dortmund, Germany., Urban S; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Seier JA; Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Adhikari B; Institute of Biochemistry, University of Kiel, Kiel, Germany., Schwalm MP; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences (BMLS), Frankfurt am Main, Germany., Müller J; Institute of Biochemistry, University of Kiel, Kiel, Germany., Dorsch M; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Steinbach P; Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Jung J; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; German Cancer Consortium, DKTK partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany., Vogt M; Institute of Biochemistry, University of Kiel, Kiel, Germany., Kaschani F; Faculty of Biology and Analytics Core Facility Essen (ACE), University of Duisburg-Essen, Essen, Germany., Koch J; Imaging Center Campus Essen, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany., Führer S; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.; Max Planck Institute of Molecular Physiology, Dortmund, Germany., Kaiser M; Faculty of Biology and Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany., Schulze N; Imaging Center Campus Essen, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences (BMLS), Frankfurt am Main, Germany.; German Cancer Consortium, DKTK partner site Frankfurt-Mainz, German Cancer Research Center (DKFZ), Heidelberg, Germany., Wolf E; Institute of Biochemistry, University of Kiel, Kiel, Germany., Paschen A; Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. annette.paschen@uk-essen.de., Grüner BM; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. barbara.gruener@uk-essen.de.; German Cancer Consortium, DKTK partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany. barbara.gruener@uk-essen.de., Gersch M; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany. malte.gersch@tu-dortmund.de.; Max Planck Institute of Molecular Physiology, Dortmund, Germany. malte.gersch@tu-dortmund.de. |
| Source: | Nature communications [Nat Commun] 2026 May 13; Vol. 17 (1). Date of Electronic Publication: 2026 May 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-72295-x |
