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Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors.

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Title: Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors.
Authors: Klink N; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.; Max Planck Institute of Molecular Physiology, Dortmund, Germany., Urban S; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Seier JA; Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Adhikari B; Institute of Biochemistry, University of Kiel, Kiel, Germany., Schwalm MP; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences (BMLS), Frankfurt am Main, Germany., Müller J; Institute of Biochemistry, University of Kiel, Kiel, Germany., Dorsch M; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Steinbach P; Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Jung J; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; German Cancer Consortium, DKTK partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany., Vogt M; Institute of Biochemistry, University of Kiel, Kiel, Germany., Kaschani F; Faculty of Biology and Analytics Core Facility Essen (ACE), University of Duisburg-Essen, Essen, Germany., Koch J; Imaging Center Campus Essen, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany., Führer S; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.; Max Planck Institute of Molecular Physiology, Dortmund, Germany., Kaiser M; Faculty of Biology and Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany., Schulze N; Imaging Center Campus Essen, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences (BMLS), Frankfurt am Main, Germany.; German Cancer Consortium, DKTK partner site Frankfurt-Mainz, German Cancer Research Center (DKFZ), Heidelberg, Germany., Wolf E; Institute of Biochemistry, University of Kiel, Kiel, Germany., Paschen A; Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. annette.paschen@uk-essen.de., Grüner BM; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. barbara.gruener@uk-essen.de.; German Cancer Consortium, DKTK partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany. barbara.gruener@uk-essen.de., Gersch M; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany. malte.gersch@tu-dortmund.de.; Max Planck Institute of Molecular Physiology, Dortmund, Germany. malte.gersch@tu-dortmund.de.
Source: Nature communications [Nat Commun] 2026 May 13; Vol. 17 (1). Date of Electronic Publication: 2026 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Klink+N%22">Klink N</searchLink>; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.; Max Planck Institute of Molecular Physiology, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Urban+S%22">Urban S</searchLink>; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Seier+JA%22">Seier JA</searchLink>; Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Adhikari+B%22">Adhikari B</searchLink>; Institute of Biochemistry, University of Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Schwalm+MP%22">Schwalm MP</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences (BMLS), Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+J%22">Müller J</searchLink>; Institute of Biochemistry, University of Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Dorsch+M%22">Dorsch M</searchLink>; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Steinbach+P%22">Steinbach P</searchLink>; Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Jung+J%22">Jung J</searchLink>; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; German Cancer Consortium, DKTK partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Vogt+M%22">Vogt M</searchLink>; Institute of Biochemistry, University of Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Kaschani+F%22">Kaschani F</searchLink>; Faculty of Biology and Analytics Core Facility Essen (ACE), University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Koch+J%22">Koch J</searchLink>; Imaging Center Campus Essen, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Führer+S%22">Führer S</searchLink>; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.; Max Planck Institute of Molecular Physiology, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Kaiser+M%22">Kaiser M</searchLink>; Faculty of Biology and Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+N%22">Schulze N</searchLink>; Imaging Center Campus Essen, Center of Medical Biotechnology, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Knapp+S%22">Knapp S</searchLink>; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.; Structural Genomics Consortium (SGC), Buchmann Institute for Molecular Life Sciences (BMLS), Frankfurt am Main, Germany.; German Cancer Consortium, DKTK partner site Frankfurt-Mainz, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+E%22">Wolf E</searchLink>; Institute of Biochemistry, University of Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Paschen+A%22">Paschen A</searchLink>; Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. annette.paschen@uk-essen.de.<br /><searchLink fieldCode="AU" term="%22Grüner+BM%22">Grüner BM</searchLink>; West German Cancer Center, Department of Medical Oncology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. barbara.gruener@uk-essen.de.; German Cancer Consortium, DKTK partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany. barbara.gruener@uk-essen.de.<br /><searchLink fieldCode="AU" term="%22Gersch+M%22">Gersch M</searchLink>; Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany. malte.gersch@tu-dortmund.de.; Max Planck Institute of Molecular Physiology, Dortmund, Germany. malte.gersch@tu-dortmund.de.
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