PSCA-directed nanosized bio-immune conjugates (NANO:BICs) enable selective uptake of TLR9 agonists in bladder cancer cells.

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Title: PSCA-directed nanosized bio-immune conjugates (NANO:BICs) enable selective uptake of TLR9 agonists in bladder cancer cells.
Authors: Iltzsche M; Department of Urology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Wetterling N; Department of Neurosurgery, Section Experimental Neurosurgery and Tumor Immunology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Jilek L; Department of Neurosurgery, Section Experimental Neurosurgery and Tumor Immunology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Nahhas D; Department of Urology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Hesse M; Department of Urology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Tietze S; Department of Neurosurgery, Section Experimental Neurosurgery and Tumor Immunology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Temme A; Department of Neurosurgery, Section Experimental Neurosurgery and Tumor Immunology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany.; National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Heidelberg, Germany., Thomas C; Department of Urology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Fuessel S; Department of Urology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Partner Site Dresden, Dresden, Germany., Kind B; Department of Urology, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Source: Frontiers in oncology [Front Oncol] 2026 Apr 28; Vol. 16, pp. 1739618. Date of Electronic Publication: 2026 Apr 28 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2234-943X
DOI:10.3389/fonc.2026.1739618