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Development of Bioisosteres of Iboga Alkaloids: A Step-Economical Synthesis to Enhance the Antinociceptive and Anxiolytic Activity with Neuroprotective Effects.

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Title: Development of Bioisosteres of Iboga Alkaloids: A Step-Economical Synthesis to Enhance the Antinociceptive and Anxiolytic Activity with Neuroprotective Effects.
Authors: Gupta A; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Sciences, Kolkata 700032, West Bengal, India., Bhattacharya T; Department of Physiology, UGC-CPEPA and UGC-CRNN, University of Calcutta, 92 APC Road, Kolkata 700009, West Bengal, India., Pratihar S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Sciences, Kolkata 700032, West Bengal, India., Parvage S; Department of Physiology, UGC-CPEPA and UGC-CRNN, University of Calcutta, 92 APC Road, Kolkata 700009, West Bengal, India., Sharma SN; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Sciences, Kolkata 700032, West Bengal, India., Sarkar A; Department of Pharmaceutical Technology, Bioequivalence Study Centre, University of Jadavpur, Kolkata 700032, West Bengal, India., De A; Department of Pharmaceutical Technology, Bioequivalence Study Centre, University of Jadavpur, Kolkata 700032, West Bengal, India., Karmakar S; Department of Pharmaceutical Technology, Bioequivalence Study Centre, University of Jadavpur, Kolkata 700032, West Bengal, India., Dey S; Department of Physiology, UGC-CPEPA and UGC-CRNN, University of Calcutta, 92 APC Road, Kolkata 700009, West Bengal, India., Sinha S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Sciences, Kolkata 700032, West Bengal, India.
Source: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2026 Apr 14; Vol. 9 (5), pp. 1082-1098. Date of Electronic Publication: 2026 Apr 14 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2575-9108
DOI:10.1021/acsptsci.5c00301