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Superparamagnetic iron oxide nanoparticle-driven 3-aroyl-1,4-diarylpyrrole nanocomposites (ARDAP@SPION-PEI) mediate renal cancer cell PANoptosis by regulating chromatin accessibility.

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Title: Superparamagnetic iron oxide nanoparticle-driven 3-aroyl-1,4-diarylpyrrole nanocomposites (ARDAP@SPION-PEI) mediate renal cancer cell PANoptosis by regulating chromatin accessibility.
Authors: Shen H; Department of Urology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing, 100050, China. shenhl2004@163.com.; Institute of Urology, Beijing Municipal Health Commission, Beijing, 100050, China. shenhl2004@163.com., Cui Z; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, Shanghai, 200031, China., Wu Y; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China., Puxeddu M; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy., Lai Y; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, Shanghai, 200031, China., Mo R; Department of Urology, Inner Mongolia People's Hospital, Inner Mongolia Urological Institute, Hohhot, Inner Mongolia, 010017, China., Yang B; Department of Urology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing, 100050, China.; Institute of Urology, Beijing Municipal Health Commission, Beijing, 100050, China., Niu Y; Department of Urology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing, 100050, China.; Institute of Urology, Beijing Municipal Health Commission, Beijing, 100050, China., Wen Y; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, Shanghai, 200031, China., Du X; School of Life Science and Technology, Tongji University, Shanghai, 200092, China., Silvestri R; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy. romano.silvestri@uniroma1.it., Liu T; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, Shanghai, 200031, China. liute1979@shutcm.edu.cn.
Source: Molecular biomedicine [Mol Biomed] 2026 May 15; Vol. 7 (1). Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Superparamagnetic iron oxide nanoparticle-driven 3-aroyl-1,4-diarylpyrrole nanocomposites (ARDAP@SPION-PEI) mediate renal cancer cell PANoptosis by regulating chromatin accessibility.
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  Data: <searchLink fieldCode="AU" term="%22Shen+H%22">Shen H</searchLink>; Department of Urology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing, 100050, China. shenhl2004@163.com.; Institute of Urology, Beijing Municipal Health Commission, Beijing, 100050, China. shenhl2004@163.com.<br /><searchLink fieldCode="AU" term="%22Cui+Z%22">Cui Z</searchLink>; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.<br /><searchLink fieldCode="AU" term="%22Puxeddu+M%22">Puxeddu M</searchLink>; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Lai+Y%22">Lai Y</searchLink>; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Mo+R%22">Mo R</searchLink>; Department of Urology, Inner Mongolia People's Hospital, Inner Mongolia Urological Institute, Hohhot, Inner Mongolia, 010017, China.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Department of Urology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing, 100050, China.; Institute of Urology, Beijing Municipal Health Commission, Beijing, 100050, China.<br /><searchLink fieldCode="AU" term="%22Niu+Y%22">Niu Y</searchLink>; Department of Urology, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing, 100050, China.; Institute of Urology, Beijing Municipal Health Commission, Beijing, 100050, China.<br /><searchLink fieldCode="AU" term="%22Wen+Y%22">Wen Y</searchLink>; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Du+X%22">Du X</searchLink>; School of Life Science and Technology, Tongji University, Shanghai, 200092, China.<br /><searchLink fieldCode="AU" term="%22Silvestri+R%22">Silvestri R</searchLink>; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy. romano.silvestri@uniroma1.it.<br /><searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 365 South Xiangyang Road, Shanghai, 200031, China. liute1979@shutcm.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229918283581406676%22">Molecular biomedicine</searchLink> [Mol Biomed] 2026 May 15; Vol. 7 (1). <i>Date of Electronic Publication: </i>2026 May 15.
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              Text: 2026 May 15
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