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Accelerated biological aging in bipolar disorder as determined by artificial intelligence-based electrocardiographic assessment.

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Title: Accelerated biological aging in bipolar disorder as determined by artificial intelligence-based electrocardiographic assessment.
Authors: Miola A; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Neuroscience, University of Padova, Padua, Italy., Medina-Inojosa BJ; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Cuellar-Barboza AB; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico., Prieto ML; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Facultad de Medicina, Universidad de los Andes, Santiago, Chile; Mental Health Service, Clínica Universidad de los Andes, Santiago, Chile., Morgan RJ; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Coombes BJ; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Veldic M; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Ozerdem A; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Singh B; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Gardea-Reséndez M; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico., Ercis M; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Pardo LS; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Romo-Nava F; Lindner Center of HOPE, Mason, OH, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA., McElroy SL; Lindner Center of HOPE, Mason, OH, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Biernacka JM; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Lara-Breitinger KM; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Medina-Inojosa JR; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA; Division of Cardiology, Department of Medicine and Rollins School of Public Health, Department of Epidemiology, Emory University School of Medicine, Atlanta, GA, USA., Frye MA; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA. Electronic address: mfrye@mayo.edu., Lopez-Jimenez F; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Source: Journal of affective disorders [J Affect Disord] 2026 Oct 01; Vol. 410, pp. 121968. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Miola+A%22">Miola A</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Neuroscience, University of Padova, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Medina-Inojosa+BJ%22">Medina-Inojosa BJ</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Cuellar-Barboza+AB%22">Cuellar-Barboza AB</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.<br /><searchLink fieldCode="AU" term="%22Prieto+ML%22">Prieto ML</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Facultad de Medicina, Universidad de los Andes, Santiago, Chile; Mental Health Service, Clínica Universidad de los Andes, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Morgan+RJ%22">Morgan RJ</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Coombes+BJ%22">Coombes BJ</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Veldic+M%22">Veldic M</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Ozerdem+A%22">Ozerdem A</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Singh+B%22">Singh B</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Gardea-Reséndez+M%22">Gardea-Reséndez M</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.<br /><searchLink fieldCode="AU" term="%22Ercis+M%22">Ercis M</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pardo+LS%22">Pardo LS</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Romo-Nava+F%22">Romo-Nava F</searchLink>; Lindner Center of HOPE, Mason, OH, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22McElroy+SL%22">McElroy SL</searchLink>; Lindner Center of HOPE, Mason, OH, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Biernacka+JM%22">Biernacka JM</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Lara-Breitinger+KM%22">Lara-Breitinger KM</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Medina-Inojosa+JR%22">Medina-Inojosa JR</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA; Division of Cardiology, Department of Medicine and Rollins School of Public Health, Department of Epidemiology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Frye+MA%22">Frye MA</searchLink>; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA. Electronic address: mfrye@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Lopez-Jimenez+F%22">Lopez-Jimenez F</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
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        Value: 10.1016/j.jad.2026.121968
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              Text: 2026 Oct 01
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