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A Scalable, Direct-to-Biology Platform for Accelerated Discovery of Cereblon-Based Molecular Glue Degraders.

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Title: A Scalable, Direct-to-Biology Platform for Accelerated Discovery of Cereblon-Based Molecular Glue Degraders.
Authors: Wang JY; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China., Yin GL; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Chi Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Feng YP; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China., Zhou CC; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China., Nie HJ; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Zhang ZG; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Meng S; School of Pharmacy, Henan University, Zhengzhou, China., Chen Y; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.; University of Chinese Academy of Sciences, Beijing, China., Zhou ZP; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China., Zhang JY; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.; University of Chinese Academy of Sciences, Beijing, China., Xu A; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China., Xu YK; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China., Zhai L; Translational Research Institute of Brain and Brain-Like Intelligence, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China., Tan M; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Zhao D; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Chen XH; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.
Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2026 May 18, pp. e3518516. Date of Electronic Publication: 2026 May 18.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Scalable, Direct-to-Biology Platform for Accelerated Discovery of Cereblon-Based Molecular Glue Degraders.
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  Data: <searchLink fieldCode="AU" term="%22Wang+JY%22">Wang JY</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Yin+GL%22">Yin GL</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chi+Y%22">Chi Y</searchLink>; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Feng+YP%22">Feng YP</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+CC%22">Zhou CC</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Nie+HJ%22">Nie HJ</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+ZG%22">Zhang ZG</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Meng+S%22">Meng S</searchLink>; School of Pharmacy, Henan University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+ZP%22">Zhou ZP</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+JY%22">Zhang JY</searchLink>; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+A%22">Xu A</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+YK%22">Xu YK</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhai+L%22">Zhai L</searchLink>; Translational Research Institute of Brain and Brain-Like Intelligence, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Tan+M%22">Tan M</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhao+D%22">Zhao D</searchLink>; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chen+XH%22">Chen XH</searchLink>; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.
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