Condensation of cGAS induced by Tyr242 phosphorylation and interaction with MYL6 mediates vascular innate immunity in the lung.
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| Title: | Condensation of cGAS induced by Tyr242 phosphorylation and interaction with MYL6 mediates vascular innate immunity in the lung. |
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| Authors: | Joshi B; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Joshi JC; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Balaji Raghunathrao VA; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Velligiri V; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Akhter MZ; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Toth PT; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Yadavalli T; Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA., Thompson J; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Banerjee S; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Shukla D; Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA., Gaponenko V; Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, Chicago, IL 60612, USA., Komarova Y; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Mehta D; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA. |
| Source: | Science signaling [Sci Signal] 2026 May 19; Vol. 19 (938), pp. eadu6757. Date of Electronic Publication: 2026 May 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1937-9145 |
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| DOI: | 10.1126/scisignal.adu6757 |
