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Condensation of cGAS induced by Tyr242 phosphorylation and interaction with MYL6 mediates vascular innate immunity in the lung.

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Title: Condensation of cGAS induced by Tyr242 phosphorylation and interaction with MYL6 mediates vascular innate immunity in the lung.
Authors: Joshi B; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Joshi JC; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Balaji Raghunathrao VA; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Velligiri V; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Akhter MZ; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Toth PT; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Yadavalli T; Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA., Thompson J; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Banerjee S; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Shukla D; Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA., Gaponenko V; Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, Chicago, IL 60612, USA., Komarova Y; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA., Mehta D; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Source: Science signaling [Sci Signal] 2026 May 19; Vol. 19 (938), pp. eadu6757. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Condensation of cGAS induced by Tyr<superscript>242</superscript> phosphorylation and interaction with MYL6 mediates vascular innate immunity in the lung.
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  Data: <searchLink fieldCode="AU" term="%22Joshi+B%22">Joshi B</searchLink>; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+JC%22">Joshi JC</searchLink>; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Balaji+Raghunathrao+VA%22">Balaji Raghunathrao VA</searchLink>; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Velligiri+V%22">Velligiri V</searchLink>; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Akhter+MZ%22">Akhter MZ</searchLink>; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Toth+PT%22">Toth PT</searchLink>; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Yadavalli+T%22">Yadavalli T</searchLink>; Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+J%22">Thompson J</searchLink>; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Banerjee+S%22">Banerjee S</searchLink>; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Shukla+D%22">Shukla D</searchLink>; Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Gaponenko+V%22">Gaponenko V</searchLink>; Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Komarova+Y%22">Komarova Y</searchLink>; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+D%22">Mehta D</searchLink>; Department of Pharmacology and Regenerative Medicine, Centre for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
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