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Tempered Optimism: Advances in the Precision Medicine Era for Pediatric Low-Grade Glioma.

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Title: Tempered Optimism: Advances in the Precision Medicine Era for Pediatric Low-Grade Glioma.
Authors: Kotch C; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Perreault S; Division of Child Neurology, Department of Neurosciences, Université de Montréal, Montréal, QC, H3T 1J4, Canada., Power P; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.; Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia., Adams DJ; Wellcome Trust Sanger Institute, Cambridge, UK., Aldape K; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Avery RA; Division of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Bandopadhayay P; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Cambridge, Massachusetts, USA., Capper D; Department of Neuropathology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany., de Blank P; Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Entz-Werle N; Pediatric Oncology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France, EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, France., Fangusaro J; Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA; Aflac Cancer Center, Atlanta, Georgia, USA., Hansford JR; Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital; Pediatric Neuro-Oncology, Precision Cancer Medicine, South Australia Health and Medical Research Institute; South Australia Immunogenomics Cancer Institute, Adelaide University, Adelaide, South Australia, Australia., Hawkins C; Arthur and Sonia Labatt Brain Tumour Research Centre, SickKids Research Institute, Toronto, Ontario, Canada., Jacques TS, Jones DT; German Cancer Research Center (DKFZ), Hopp Children's Cancer Center Heidelberg (KiTZ) and Division of Pediatric Glioma Research (B360), Heidelberg, Germany., Kann BH; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, USA and Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Kranendonk ME; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Levine A; Arthur and Sonia Labatt Brain Tumour Research Centre, SickKids Research Institute, Toronto, Ontario, Canada., Ligon KL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Martinez-Barbera JP; Developmental Biology and Cancer, UCL GOS Institute of Child Health, London, UK., Meijer L; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Milde T; German Cancer Research Center (DKFZ), Hopp Children's Cancer Center Heidelberg (KiTZ) and Division of Pediatric Glioma Research (B360), Heidelberg, Germany.; University Hospital Jena, Department of Pediatrics and Adolescent Medicine, Friedrich Schiller University Jena, Jena, Germany and Comprehensive Cancer Center Central Germany (CCCG), Jena, Germany., Mueller S; Department of Neurology and Pediatrics, University of California San Francisco, San Francisco, California, USA., Mulcahy Levy JM; Morgan Adams Foundation Brain Tumor Research Program, Department of Pediatrics, Children's Hospital Colorado, and University of Colorado School of Medicine, Aurora, Colorado, USA., Nakano Y; Department of Histopathology, Great Ormond Street Hospital for Children, UCL GOS Institute of Child Health, London, UK., Packer RJ; Brain Tumor Institute and Gilbert Family Neurofibromatosis Institute, Children's National Hospital, Washington, District of Columbia, USA.; Division of Oncology, Children's National Hospital, Washington, District of Columbia, USA., Pfister S; German Cancer Research Center (DKFZ), Hopp Children's Cancer Center Heidelberg (KiTZ) and Division of Pediatric Glioma Research (B360), Heidelberg, Germany., Raabe E; Division of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Robison NJ; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California, USA., Tabori U; Arthur and Sonia Labatt Brain Tumour Research Centre, SickKids Research Institute, Toronto, Ontario, Canada., Yeo KK; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA., Vinitsky A; St Jude Children's Research Hospital, Memphis, Tennessee, 38103, USA., Zhu Y; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Fisher MJ; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Hargrave D; University College London Great Ormond Street Institute of Child Health, London, UK., Kilburn LB; Division of Oncology, Children's National Hospital, Washington, District of Columbia, USA.
Source: Neuro-oncology [Neuro Oncol] 2026 May 19. Date of Electronic Publication: 2026 May 19.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
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Pediatric Oncology Department, University Hospitals of Strasbourg, 67098, Strasbourg, France, EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Fangusaro+J%22">Fangusaro J</searchLink>; Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA; Aflac Cancer Center, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Hansford+JR%22">Hansford JR</searchLink>; Michael Rice Centre for Hematology and Oncology, Women's and Children's Hospital; Pediatric Neuro-Oncology, Precision Cancer Medicine, South Australia Health and Medical Research Institute; South Australia Immunogenomics Cancer Institute, Adelaide University, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Hawkins+C%22">Hawkins C</searchLink>; Arthur and Sonia Labatt Brain Tumour Research Centre, SickKids Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Jacques+TS%22">Jacques TS</searchLink><br /><searchLink fieldCode="AU" term="%22Jones+DT%22">Jones DT</searchLink>; German Cancer Research Center (DKFZ), Hopp Children's Cancer Center Heidelberg (KiTZ) and Division of Pediatric Glioma Research (B360), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kann+BH%22">Kann BH</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts, USA and Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kranendonk+ME%22">Kranendonk ME</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Levine+A%22">Levine A</searchLink>; Arthur and Sonia Labatt Brain Tumour Research Centre, SickKids Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ligon+KL%22">Ligon KL</searchLink>; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Martinez-Barbera+JP%22">Martinez-Barbera JP</searchLink>; Developmental Biology and Cancer, UCL GOS Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Meijer+L%22">Meijer L</searchLink>; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Milde+T%22">Milde T</searchLink>; German Cancer Research Center (DKFZ), Hopp Children's Cancer Center Heidelberg (KiTZ) and Division of Pediatric Glioma Research (B360), Heidelberg, Germany.; University Hospital Jena, Department of Pediatrics and Adolescent Medicine, Friedrich Schiller University Jena, Jena, Germany and Comprehensive Cancer Center Central Germany (CCCG), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Mueller+S%22">Mueller S</searchLink>; Department of Neurology and Pediatrics, University of California San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Mulcahy+Levy+JM%22">Mulcahy Levy JM</searchLink>; Morgan Adams Foundation Brain Tumor Research Program, Department of Pediatrics, Children's Hospital Colorado, and University of Colorado School of Medicine, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Nakano+Y%22">Nakano Y</searchLink>; Department of Histopathology, Great Ormond Street Hospital for Children, UCL GOS Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Packer+RJ%22">Packer RJ</searchLink>; Brain Tumor Institute and Gilbert Family Neurofibromatosis Institute, Children's National Hospital, Washington, District of Columbia, USA.; Division of Oncology, Children's National Hospital, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Pfister+S%22">Pfister S</searchLink>; German Cancer Research Center (DKFZ), Hopp Children's Cancer Center Heidelberg (KiTZ) and Division of Pediatric Glioma Research (B360), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Raabe+E%22">Raabe E</searchLink>; Division of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Robison+NJ%22">Robison NJ</searchLink>; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Tabori+U%22">Tabori U</searchLink>; Arthur and Sonia Labatt Brain Tumour Research Centre, SickKids Research Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Yeo+KK%22">Yeo KK</searchLink>; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Vinitsky+A%22">Vinitsky A</searchLink>; St Jude Children's Research Hospital, Memphis, Tennessee, 38103, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Fisher+MJ%22">Fisher MJ</searchLink>; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hargrave+D%22">Hargrave D</searchLink>; University College London Great Ormond Street Institute of Child Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Kilburn+LB%22">Kilburn LB</searchLink>; Division of Oncology, Children's National Hospital, Washington, District of Columbia, USA.
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