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NRF2 as a guardian of health: from an ancient survival pathway to a modern therapeutic target.

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Title: NRF2 as a guardian of health: from an ancient survival pathway to a modern therapeutic target.
Authors: Tenreiro S; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal. Electronic address: stenreiro@nms.unl.pt., Falcão AS; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal., Bender N; Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland., Bernatova I; Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal and Pathological Physiology, Bratislava, Slovakia., Berry A; Center for Behavioral Sciences and Mental Health, Instituto Superiore di Sanità, Rome, Italy., Cuadrado A; Department of Biochemistry, Medical College, Autonomous University of Madrid (UAM), Madrid, Spain., Eppenberger P; Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland., Giona L; Center for Behavioral Sciences and Mental Health, Instituto Superiore di Sanità, Rome, Italy; Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy., Grochot-Przeczek A; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Krakow, Poland., Heiss E; Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria., Jakubowska M; Malopolska Centre of Biotechnology, Jagiellonian University in Krakow, Krakow, Poland., Long PF; Institute of Pharmaceutical Science, King's College London, London, United Kingdom; Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil., Makhro A; Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland., Masoodi M; Faculty of Medicine, University Hospital Bern, Switzerland., Morgenstern C; Vienna Airway Lab, Department of Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria., Saso L; Department of Physiology and Pharmacology 'Vittorio Erspamer', La Sapienza University, Rome, Italy., Seabra MC; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal., Sznarkowska A; International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland., Sykiotis G; Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Trougakos IP; Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Source: Redox biology [Redox Biol] 2026 Jul; Vol. 94, pp. 104217. Date of Electronic Publication: 2026 May 15.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Tenreiro+S%22">Tenreiro S</searchLink>; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal. Electronic address: stenreiro@nms.unl.pt.<br /><searchLink fieldCode="AU" term="%22Falcão+AS%22">Falcão AS</searchLink>; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal.<br /><searchLink fieldCode="AU" term="%22Bender+N%22">Bender N</searchLink>; Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bernatova+I%22">Bernatova I</searchLink>; Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Normal and Pathological Physiology, Bratislava, Slovakia.<br /><searchLink fieldCode="AU" term="%22Berry+A%22">Berry A</searchLink>; Center for Behavioral Sciences and Mental Health, Instituto Superiore di Sanità, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cuadrado+A%22">Cuadrado A</searchLink>; Department of Biochemistry, Medical College, Autonomous University of Madrid (UAM), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Eppenberger+P%22">Eppenberger P</searchLink>; Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Giona+L%22">Giona L</searchLink>; Center for Behavioral Sciences and Mental Health, Instituto Superiore di Sanità, Rome, Italy; Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Grochot-Przeczek+A%22">Grochot-Przeczek A</searchLink>; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Krakow, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Heiss+E%22">Heiss E</searchLink>; Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Jakubowska+M%22">Jakubowska M</searchLink>; Malopolska Centre of Biotechnology, Jagiellonian University in Krakow, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Long+PF%22">Long PF</searchLink>; Institute of Pharmaceutical Science, King's College London, London, United Kingdom; Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Makhro+A%22">Makhro A</searchLink>; Institute of Evolutionary Medicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Masoodi+M%22">Masoodi M</searchLink>; Faculty of Medicine, University Hospital Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Morgenstern+C%22">Morgenstern C</searchLink>; Vienna Airway Lab, Department of Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Saso+L%22">Saso L</searchLink>; Department of Physiology and Pharmacology 'Vittorio Erspamer', La Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Seabra+MC%22">Seabra MC</searchLink>; iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal.<br /><searchLink fieldCode="AU" term="%22Sznarkowska+A%22">Sznarkowska A</searchLink>; International Centre for Cancer Vaccine Science, University of Gdansk, Gdansk, Poland.<br /><searchLink fieldCode="AU" term="%22Sykiotis+G%22">Sykiotis G</searchLink>; Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Trougakos+IP%22">Trougakos IP</searchLink>; Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
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  Data: <searchLink fieldCode="JN" term="%22101605639%22">Redox biology</searchLink> [Redox Biol] 2026 Jul; Vol. 94, pp. 104217. <i>Date of Electronic Publication: </i>2026 May 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2C+B%2EV%22">Elsevier, B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101605639 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2317 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132317%22">22132317 </searchLink><i>NLM ISO Abbreviation: </i>Redox Biol <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul
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