A Multicenter Phase II Study on Atezolizumab plus Bevacizumab Combination Therapy in Patients with Unresectable Hepatocellular Carcinoma and Child-Pugh Classification B Cirrhosis: CHALLENGE Trial.

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Title: A Multicenter Phase II Study on Atezolizumab plus Bevacizumab Combination Therapy in Patients with Unresectable Hepatocellular Carcinoma and Child-Pugh Classification B Cirrhosis: CHALLENGE Trial.
Authors: Terashima T; Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan.; Department of Medical Oncology, Kanazawa Medical University, Uchinada, Japan., Ikeda M; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Yamashita T; Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan., Okusaka T; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan., Imaoka H; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Kawaoka T; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan., Kobayashi S; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan., Ogasawara S; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan., Hiraoka A; Department of Gastroenterology, Ehime Prefectural Central Hospital, Matsuyama, Japan., Nakano M; Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan., Okano N; Department of Medical Oncology, Kyorin University Faculty of Medicine, Mitaka, Japan., Sugimoto R; Department of Hepato-Biliary-Pancreatology, NHO Kyushu Cancer Center, Fukuoka, Japan., Moriguchi M; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Inaba Y; Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya, Japan., Shinoda S; Department of Biostatistics, Yokohama City University, School of Medicine, Yokohama, Japan., Ueno M; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan., Kudo M; Department of Gastroenterology and Hepatology, Kindai University Hospital, Osaka-Sayama, Japan., Furuse J; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan., Nagano H; Department of Gastroenterological, Breast, and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
Source: Liver cancer [Liver Cancer] 2026 Mar 12. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: S. Karger Country of Publication: Switzerland NLM ID: 101597993 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2235-1795 (Print) Linking ISSN: 16645553 NLM ISO Abbreviation: Liver Cancer
Database: MEDLINE Ultimate
Description
ISSN:2235-1795
DOI:10.1159/000551476