A Multicenter Phase II Study on Atezolizumab plus Bevacizumab Combination Therapy in Patients with Unresectable Hepatocellular Carcinoma and Child-Pugh Classification B Cirrhosis: CHALLENGE Trial.
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| Title: | A Multicenter Phase II Study on Atezolizumab plus Bevacizumab Combination Therapy in Patients with Unresectable Hepatocellular Carcinoma and Child-Pugh Classification B Cirrhosis: CHALLENGE Trial. |
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| Authors: | Terashima T; Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan.; Department of Medical Oncology, Kanazawa Medical University, Uchinada, Japan., Ikeda M; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Yamashita T; Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan., Okusaka T; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan., Imaoka H; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Kawaoka T; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan., Kobayashi S; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan., Ogasawara S; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan., Hiraoka A; Department of Gastroenterology, Ehime Prefectural Central Hospital, Matsuyama, Japan., Nakano M; Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan., Okano N; Department of Medical Oncology, Kyorin University Faculty of Medicine, Mitaka, Japan., Sugimoto R; Department of Hepato-Biliary-Pancreatology, NHO Kyushu Cancer Center, Fukuoka, Japan., Moriguchi M; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Inaba Y; Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya, Japan., Shinoda S; Department of Biostatistics, Yokohama City University, School of Medicine, Yokohama, Japan., Ueno M; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan., Kudo M; Department of Gastroenterology and Hepatology, Kindai University Hospital, Osaka-Sayama, Japan., Furuse J; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan., Nagano H; Department of Gastroenterological, Breast, and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan. |
| Source: | Liver cancer [Liver Cancer] 2026 Mar 12. Date of Electronic Publication: 2026 Mar 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: S. Karger Country of Publication: Switzerland NLM ID: 101597993 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2235-1795 (Print) Linking ISSN: 16645553 NLM ISO Abbreviation: Liver Cancer |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42158105 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A Multicenter Phase II Study on Atezolizumab plus Bevacizumab Combination Therapy in Patients with Unresectable Hepatocellular Carcinoma and Child-Pugh Classification B Cirrhosis: CHALLENGE Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Terashima+T%22">Terashima T</searchLink>; Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan.; Department of Medical Oncology, Kanazawa Medical University, Uchinada, Japan.<br /><searchLink fieldCode="AU" term="%22Ikeda+M%22">Ikeda M</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Yamashita+T%22">Yamashita T</searchLink>; Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan.<br /><searchLink fieldCode="AU" term="%22Okusaka+T%22">Okusaka T</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Imaoka+H%22">Imaoka H</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Kawaoka+T%22">Kawaoka T</searchLink>; Department of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+S%22">Kobayashi S</searchLink>; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ogasawara+S%22">Ogasawara S</searchLink>; Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Hiraoka+A%22">Hiraoka A</searchLink>; Department of Gastroenterology, Ehime Prefectural Central Hospital, Matsuyama, Japan.<br /><searchLink fieldCode="AU" term="%22Nakano+M%22">Nakano M</searchLink>; Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.<br /><searchLink fieldCode="AU" term="%22Okano+N%22">Okano N</searchLink>; Department of Medical Oncology, Kyorin University Faculty of Medicine, Mitaka, Japan.<br /><searchLink fieldCode="AU" term="%22Sugimoto+R%22">Sugimoto R</searchLink>; Department of Hepato-Biliary-Pancreatology, NHO Kyushu Cancer Center, Fukuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Moriguchi+M%22">Moriguchi M</searchLink>; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Inaba+Y%22">Inaba Y</searchLink>; Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Shinoda+S%22">Shinoda S</searchLink>; Department of Biostatistics, Yokohama City University, School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ueno+M%22">Ueno M</searchLink>; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Kudo+M%22">Kudo M</searchLink>; Department of Gastroenterology and Hepatology, Kindai University Hospital, Osaka-Sayama, Japan.<br /><searchLink fieldCode="AU" term="%22Furuse+J%22">Furuse J</searchLink>; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Nagano+H%22">Nagano H</searchLink>; Department of Gastroenterological, Breast, and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101597993%22">Liver cancer</searchLink> [Liver Cancer] 2026 Mar 12. <i>Date of Electronic Publication: </i>2026 Mar 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22S%2E+Karger%22">S. Karger </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101597993 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2235-1795 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216645553%22">16645553 </searchLink><i>NLM ISO Abbreviation: </i>Liver Cancer |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42158105 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1159/000551476 Languages: – Code: eng Text: English Titles: – TitleFull: A Multicenter Phase II Study on Atezolizumab plus Bevacizumab Combination Therapy in Patients with Unresectable Hepatocellular Carcinoma and Child-Pugh Classification B Cirrhosis: CHALLENGE Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Terashima T – PersonEntity: Name: NameFull: Ikeda M – PersonEntity: Name: NameFull: Yamashita T – PersonEntity: Name: NameFull: Okusaka T – PersonEntity: Name: NameFull: Imaoka H – PersonEntity: Name: NameFull: Kawaoka T – PersonEntity: Name: NameFull: Kobayashi S – PersonEntity: Name: NameFull: Ogasawara S – PersonEntity: Name: NameFull: Hiraoka A – PersonEntity: Name: NameFull: Nakano M – PersonEntity: Name: NameFull: Okano N – PersonEntity: Name: NameFull: Sugimoto R – PersonEntity: Name: NameFull: Moriguchi M – PersonEntity: Name: NameFull: Inaba Y – PersonEntity: Name: NameFull: Shinoda S – PersonEntity: Name: NameFull: Ueno M – PersonEntity: Name: NameFull: Kudo M – PersonEntity: Name: NameFull: Furuse J – PersonEntity: Name: NameFull: Nagano H IsPartOfRelationships: – BibEntity: Dates: – D: 12 M: 03 Text: 2026 Mar 12 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 2235-1795 Titles: – TitleFull: Liver cancer Type: main |
| ResultId | 1 |
