Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements.

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Title: Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements.
Authors: Psarias G; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland., Ziros PG; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland. Electronic address: panos.ziros@chuv.ch., Mageiropoulou A; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland., Chartoumpekis DV; Division of Endocrinology, School of Medicine, University of Patras, Patras, 26500, Greece., Habeos GI; Division of Endocrinology, School of Medicine, University of Patras, Patras, 26500, Greece., Alomair BM; Department of Internal Medicine, College of Medicine, Jouf University, Aljouf, 04631, Kingdom of Saudi Arabia., Duntas L; Evgenidion Hospital Unit of Endocrinology, Diabetes, and Metabolism, Thyroid Section, National and Kapodistrian University of Athens, Athens, Greece., Trougakos IP; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 15784, Greece., Sykiotis GP; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland. Electronic address: gerasimos.sykiotis@chuv.ch.
Source: Redox biology [Redox Biol] 2026 Jul; Vol. 94, pp. 104222. Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
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  Data: Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements.
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  Data: <searchLink fieldCode="AU" term="%22Psarias+G%22">Psarias G</searchLink>; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ziros+PG%22">Ziros PG</searchLink>; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland. Electronic address: panos.ziros@chuv.ch.<br /><searchLink fieldCode="AU" term="%22Mageiropoulou+A%22">Mageiropoulou A</searchLink>; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chartoumpekis+DV%22">Chartoumpekis DV</searchLink>; Division of Endocrinology, School of Medicine, University of Patras, Patras, 26500, Greece.<br /><searchLink fieldCode="AU" term="%22Habeos+GI%22">Habeos GI</searchLink>; Division of Endocrinology, School of Medicine, University of Patras, Patras, 26500, Greece.<br /><searchLink fieldCode="AU" term="%22Alomair+BM%22">Alomair BM</searchLink>; Department of Internal Medicine, College of Medicine, Jouf University, Aljouf, 04631, Kingdom of Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Duntas+L%22">Duntas L</searchLink>; Evgenidion Hospital Unit of Endocrinology, Diabetes, and Metabolism, Thyroid Section, National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Trougakos+IP%22">Trougakos IP</searchLink>; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 15784, Greece.<br /><searchLink fieldCode="AU" term="%22Sykiotis+GP%22">Sykiotis GP</searchLink>; Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland. Electronic address: gerasimos.sykiotis@chuv.ch.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2C+B%2EV%22">Elsevier, B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101605639 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2317 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132317%22">22132317 </searchLink><i>NLM ISO Abbreviation: </i>Redox Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.redox.2026.104222
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              Text: 2026 Jul
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