Loop dynamics govern MALT1 activation revealed by integrative AlphaFold, MD, and NMR analysis.
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| Title: | Loop dynamics govern MALT1 activation revealed by integrative AlphaFold, MD, and NMR analysis. |
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| Authors: | Lesovoy D; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997, Moscow, Russia., Agback T; Department of Molecular Sciences, Swedish University of Agricultural Sciences, PO Box 7015, 750 07, Uppsala, Sweden.; Department of Chemistry and Molecular Biology, University of Gothenburg, Box 465, 40530, Gothenburg, Sweden., Roshchin K; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997, Moscow, Russia., Sandalova T; Science for Life Laboratory, Department of Medicine, Karolinska Institute, 17165, Solna, Sweden.; Division of Infectious Diseases, Karolinska University Hospital, 171 76, Stockholm, Sweden., Achour A; Science for Life Laboratory, Department of Medicine, Karolinska Institute, 17165, Solna, Sweden.; Division of Infectious Diseases, Karolinska University Hospital, 171 76, Stockholm, Sweden., Han X; Science for Life Laboratory, Department of Medicine, Karolinska Institute, 17165, Solna, Sweden.; Division of Infectious Diseases, Karolinska University Hospital, 171 76, Stockholm, Sweden., Lomzov A; Laboratory of Structural Biology, Institute of Chemical Biology and Fundamental Medicine SB RAS, 630090, Novosibirsk, Russia., Orekhov V; Department of Chemistry and Molecular Biology, University of Gothenburg, Box 465, 40530, Gothenburg, Sweden. vladislav.orekhov@nmr.gu.se.; Swedish NMR Centre, Science for Life Laboratory, SciLifeLab, University of Gothenburg, Box 465, 40530, Gothenburg, Sweden. vladislav.orekhov@nmr.gu.se., Agback P; Department of Molecular Sciences, Swedish University of Agricultural Sciences, PO Box 7015, 750 07, Uppsala, Sweden. peter.agback@slu.se. |
| Source: | Scientific reports [Sci Rep] 2026 May 20; Vol. 16 (1). Date of Electronic Publication: 2026 May 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-026-53505-4 |
