An opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol.

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Title: An opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol.
Authors: P A Costa G; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Clinical Neuroscience Research Unit (CNRU), Connecticut Mental Health Center (CMHC), New Haven, CT, USA., Sofuoglu M; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; Clinical Neuroscience Research Unit (CNRU), Connecticut Mental Health Center (CMHC), New Haven, CT, USA.; VA Connecticut Healthcare System, West Haven, CT, USA., Compton P; Department of Family and Community Health, University of Pennsylvania School of Nursing, Philadelphia, PA, USA., Ranganathan M; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; VA Connecticut Healthcare System, West Haven, CT, USA., Pittman B; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., De Aquino JP; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. joao.deaquino@yale.edu.; Clinical Neuroscience Research Unit (CNRU), Connecticut Mental Health Center (CMHC), New Haven, CT, USA. joao.deaquino@yale.edu.; VA Connecticut Healthcare System, West Haven, CT, USA. joao.deaquino@yale.edu.
Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2026 May 20. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1740-634X
DOI:10.1038/s41386-026-02443-w