The novel GLP-1/GIP dual receptor agonist DA5-CH is superior to tirzepatide and exendin-4 in the 6-OHDA Parkinson rat model.

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Title: The novel GLP-1/GIP dual receptor agonist DA5-CH is superior to tirzepatide and exendin-4 in the 6-OHDA Parkinson rat model.
Authors: Lingyu Z; Experimental Animal Center of Shanxi Medical University, Shanxi Key Laboratory of Human Disease and Animal Models, Taiyuan, Shanxi, China., Peng F; Second Hospital, Neurology Department, Shanxi Medical University, Taiyuan, Shanxi, China., Wanting Z; School of Medical Science, Shanxi Medical University, Taiyuan, Shanxi, China., Qianqian J; Department of Forensic Pathology, Shanxi Medical University, Taiyuan, Shanxi, China., Zhang Z; School of Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China., Bai B; Second Hospital, Neurology Department, Shanxi Medical University, Taiyuan, Shanxi, China., Xue G; Second Hospital, Neurology Department, Shanxi Medical University, Taiyuan, Shanxi, China., Hölscher C; Second Hospital, Neurology Department, Shanxi Medical University, Taiyuan, Shanxi, China.
Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2026 May 05; Vol. 17, pp. 1825379. Date of Electronic Publication: 2026 May 05 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-2392
DOI:10.3389/fendo.2026.1825379