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Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models.

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Title: Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models.
Authors: Wang P; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; Department of Histology and Embryology, College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China.; Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China., Du S; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Wu S; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Zhai Y; Division of Gastroenterology and Hepatology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China., Bai J; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China., Safdar A; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Liu Z; Division of Gastroenterology and Hepatology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China., Lu Z; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Li B; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China., Cheng J; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Song Y; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China., Zhang R; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100084, China., Li D; Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China., Wang Z; Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China., Zeng Z; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100084, China., Nie G; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Chang YZ; Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China., Li S; Beijing Key Laboratory for Drug Delivery Nanocarriers, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.; College of Materials Science and Opto-Electronics Technology, College of Nanoscience and Engineering, School of Advanced Interdisciplinary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Source: Science translational medicine [Sci Transl Med] 2026 Jun 03; Vol. 18 (852), pp. eaea0189. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.aea0189