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Paeonol ameliorates scopolamine- and β-amyloid 1-42 oligomer-induced cognitive impairments through modulation of the TGR5-PKA-cAMP response element-binding-brain-derived neurotrophic factor pathway and inhibition of acetylcholinesterase.

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Title: Paeonol ameliorates scopolamine- and β-amyloid 1-42 oligomer-induced cognitive impairments through modulation of the TGR5-PKA-cAMP response element-binding-brain-derived neurotrophic factor pathway and inhibition of acetylcholinesterase.
Authors: Lee YW; Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea., Cho YE; Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea., Kim SY; Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon, 24341, Republic of Korea., Cho SY; Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea., Lee SJ; Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea., Do YJ; Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea., Lee NH; Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea., Kim DH; Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, Seoul, 05029, Republic of Korea., Ryu JH; Department of Biomedical and Pharmaceutical Sciences, Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, 02447, Republic of Korea., Bae HJ; School of Advanced Bioengineering, Glocal Advanced Institute of Science and Technology, Changwon National University, Changwon, 51140, Republic of Korea. Electronic address: baehj321@changwon.ac.kr., Park SJ; Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea; Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address: sejinpark@kangwon.ac.kr.
Source: Neurochemistry international [Neurochem Int] 2026 Jul-Aug; Vol. 197, pp. 106188. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-9754
DOI:10.1016/j.neuint.2026.106188