TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis.

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Title: TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis.
Authors: Bahi A; Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman, UAE. a.bahi@ajman.ac.ae.; Center of Medical & Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE. a.bahi@ajman.ac.ae., Dreyer JL; Division of Biochemistry, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Source: Psychopharmacology [Psychopharmacology (Berl)] 2026 May 22. Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-2072
DOI:10.1007/s00213-026-07091-y