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TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis.

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Title: TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis.
Authors: Bahi A; Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman, UAE. a.bahi@ajman.ac.ae.; Center of Medical & Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE. a.bahi@ajman.ac.ae., Dreyer JL; Division of Biochemistry, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Source: Psychopharmacology [Psychopharmacology (Berl)] 2026 May 22. Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis.
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  Data: <searchLink fieldCode="AU" term="%22Bahi+A%22">Bahi A</searchLink>; Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman, UAE. a.bahi@ajman.ac.ae.; Center of Medical & Bio-Allied Health Sciences Research, Ajman University, Ajman, UAE. a.bahi@ajman.ac.ae.<br /><searchLink fieldCode="AU" term="%22Dreyer+JL%22">Dreyer JL</searchLink>; Division of Biochemistry, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%227608025%22">Psychopharmacology</searchLink> [Psychopharmacology (Berl)] 2026 May 22. <i>Date of Electronic Publication: </i>2026 May 22.
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        Value: 10.1007/s00213-026-07091-y
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        Text: English
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      – TitleFull: TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis.
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            NameFull: Bahi A
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            – D: 22
              M: 05
              Text: 2026 May 22
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              Y: 2026
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