SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children.

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Title: SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children.
Authors: Xu Q; Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Shi L; Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Liu C; Department of Immunobiology; Yale Center for Systems and Engineering Immunology, Yale School of Medicine, New Haven, CT, USA., Kabat J; Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Behzadpour H; Division of Pediatric Otolaryngology, Children's National Hospital, Washington, DC, USA., Kardava L; B-Cell Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Markowitz TE; Integrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Smelkinson M; Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Hoehn KB; Department of Biomedical Data Science and Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Buckner CM; B-Cell Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Golec DP; Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Bellusci L; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Grubbs G; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Pourhashemi S; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Tang J; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Khleborodova A; Integrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Kirby M; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Sparks R; Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Martins AJ; Department of Immunobiology; Yale Center for Systems and Engineering Immunology, Yale School of Medicine, New Haven, CT, USA., Tsang JS; Department of Immunobiology; Yale Center for Systems and Engineering Immunology, Yale School of Medicine, New Haven, CT, USA.; Department of Biomedical Engineering, Yale University, New Haven, CT, USA., Moir S; Integrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA., Mudd P; Division of Pediatric Otolaryngology, Children's National Hospital, Washington, DC, USA.; Division of Otolaryngology, Department of Surgery, George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Schwartzberg PL; Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. pamela.schwartzberg@nih.gov., Manthiram K; Cell Signaling and Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. kalpana.manthiram@nih.gov.
Corporate Authors: Center for Human Immunology
Source: Nature communications [Nat Commun] 2026 May 22. Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-72996-3