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In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology.

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Title: In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology.
Authors: Jiang Q; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Hu JN; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China.; Shigatse Branch, Xinqiao Hospital, Army Medical University (Third Military Medical University), Tibet, 857012, China., Dong HM; Department of Cognitive Impairment Research, Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, 401336, China., Xin JY; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Shi AY; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Zeng GH; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China., Liu J; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China. 17721056469@163.com.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China. 17721056469@163.com.; Department of Cognitive Impairment Research, Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, 401336, China. 17721056469@163.com., Wang YJ; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, 400042, China. yanjiang_wang@tmmu.edu.cn.
Source: Molecular neurodegeneration [Mol Neurodegener] 2026 May 23. Date of Electronic Publication: 2026 May 23.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1750-1326
DOI:10.1186/s13024-026-00956-y