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Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation.

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Title: Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation.
Authors: Fan HY; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan., Hsieh CC; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan., Chen TP; Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA., Lai PJ; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan., Hsu HY; Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.; Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan.; Department of Medicine, MacKay Medical University, New Taipei City, Taiwan., Yeh CL; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan., Wu CW; Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan.; Brain and Consciousness Research Center, Shuang Ho Hospital-Taipei Medical University, Taipei, Taiwan., Chien KL; Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan., Huang HY; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan., Tung YT; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan. peggytung@nchu.edu.tw.; Advanced Plant and Food Crop Biotechnology Center, National Chung Hsing University, Taichung City, Taiwan. peggytung@nchu.edu.tw.; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. peggytung@nchu.edu.tw.
Source: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2026 May 24; Vol. 22 (3). Date of Electronic Publication: 2026 May 24.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101274889 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-3890 (Electronic) Linking ISSN: 15733882 NLM ISO Abbreviation: Metabolomics Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation.
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  Data: <searchLink fieldCode="AU" term="%22Fan+HY%22">Fan HY</searchLink>; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+CC%22">Hsieh CC</searchLink>; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+TP%22">Chen TP</searchLink>; Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Lai+PJ%22">Lai PJ</searchLink>; School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+HY%22">Hsu HY</searchLink>; Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.; Department of Family Medicine, Mackay Memorial Hospital, Taipei, Taiwan.; Department of Medicine, MacKay Medical University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+CL%22">Yeh CL</searchLink>; School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+CW%22">Wu CW</searchLink>; Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, Taiwan.; Brain and Consciousness Research Center, Shuang Ho Hospital-Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chien+KL%22">Chien KL</searchLink>; Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+HY%22">Huang HY</searchLink>; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tung+YT%22">Tung YT</searchLink>; Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan. peggytung@nchu.edu.tw.; Advanced Plant and Food Crop Biotechnology Center, National Chung Hsing University, Taichung City, Taiwan. peggytung@nchu.edu.tw.; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. peggytung@nchu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101274889%22">Metabolomics : Official journal of the Metabolomic Society</searchLink> [Metabolomics] 2026 May 24; Vol. 22 (3). <i>Date of Electronic Publication: </i>2026 May 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101274889 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-3890 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215733882%22">15733882 </searchLink><i>NLM ISO Abbreviation: </i>Metabolomics <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11306-026-02450-4
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      – Code: eng
        Text: English
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      – TitleFull: Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation.
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            – D: 24
              M: 05
              Text: 2026 May 24
              Type: published
              Y: 2026
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