Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis.
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| Title: | Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis. |
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| Authors: | Wang Y; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China.; Tianfu Jincheng Laboratory, Chengdu, China., Zhang X; Department of Biomedical Sciences, College of Biomedicine, Institute of Digital Medicine, Tung Biomedical Science Center, The Shenzhen Research Institute and Futian Research Institute, City University of Hong Kong, Hong Kong, China.; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Wang N; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China.; WeiFang People's Hospital, Shandong Second Medical University, Shandong, China., Jiang H; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China., Liang N; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China.; Department of Biomedical Sciences, College of Biomedicine, Institute of Digital Medicine, Tung Biomedical Science Center, The Shenzhen Research Institute and Futian Research Institute, City University of Hong Kong, Hong Kong, China., Du C; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Yin C; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China.; Department of Biomedical Sciences, College of Biomedicine, Institute of Digital Medicine, Tung Biomedical Science Center, The Shenzhen Research Institute and Futian Research Institute, City University of Hong Kong, Hong Kong, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Li R; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China.; Department of Biomedical Sciences, College of Biomedicine, Institute of Digital Medicine, Tung Biomedical Science Center, The Shenzhen Research Institute and Futian Research Institute, City University of Hong Kong, Hong Kong, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Zhang L; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China., Tu Q; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Lv J; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China., Ma H; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China., Xu X; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China., Kong X; Renji Hospital, Shanghai Jiao Tong University, Shanghai, China., Chen X; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China., Liu G; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China., Chen S; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China., Xu H; Department of Biomedical Sciences, College of Biomedicine, Institute of Digital Medicine, Tung Biomedical Science Center, The Shenzhen Research Institute and Futian Research Institute, City University of Hong Kong, Hong Kong, China., Qin J; Renji Hospital, Shanghai Jiao Tong University, Shanghai, China., Li S; Organ Transplant Center, Shanghai Chang Zheng Hospital, 2nd Hospital Affiliated with Naval Medical University, Shanghai, China., Tao Y; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China., Zeng S; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Shen H; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Goncalves MD; NYU Grossman School of Medicine, New York, NY, USA., Zhong S; Department of Biomedical Sciences, College of Biomedicine, Institute of Digital Medicine, Tung Biomedical Science Center, The Shenzhen Research Institute and Futian Research Institute, City University of Hong Kong, Hong Kong, China. shazhong@cityu.edu.hk., Yin H; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Research, Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, Beijing, China. huiyoyin@cityu.edu.hk.; Tianfu Jincheng Laboratory, Chengdu, China. huiyoyin@cityu.edu.hk.; Department of Biomedical Sciences, College of Biomedicine, Institute of Digital Medicine, Tung Biomedical Science Center, The Shenzhen Research Institute and Futian Research Institute, City University of Hong Kong, Hong Kong, China. huiyoyin@cityu.edu.hk.; School of Life Science and Technology, ShanghaiTech University, Shanghai, China. huiyoyin@cityu.edu.hk. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 May 25; Vol. 11 (1). Date of Electronic Publication: 2026 May 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02695-4 |
