Supercharging the metabolic engine: mitochondrial engineering strategies for CAR-T persistence in solid tumors.

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Title: Supercharging the metabolic engine: mitochondrial engineering strategies for CAR-T persistence in solid tumors.
Authors: Chun S; Translational-Transdisciplinary Research Center, Medical Science Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.; Department of Medicine, Kyung Hee University College of Medicine, Seoul, Republic of Korea., Yu S; Translational-Transdisciplinary Research Center, Medical Science Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.; Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul, Republic of Korea.; Center for Space Biomedical Science, NEXUS Institute, Kyung Hee University, Yongin, Republic of Korea., Lee HG; Department of Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea., Kim MS; Translational-Transdisciplinary Research Center, Medical Science Research Institute, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.; Department of Medicine, Kyung Hee University College of Medicine, Seoul, Republic of Korea.; Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul, Republic of Korea.; Center for Space Biomedical Science, NEXUS Institute, Kyung Hee University, Yongin, Republic of Korea.
Source: Frontiers in immunology [Front Immunol] 2026 May 08; Vol. 17, pp. 1822668. Date of Electronic Publication: 2026 May 08 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2026.1822668