Sequential versus concurrent neoadjuvant immunochemotherapy in locally advanced esophageal squamous cell carcinoma: a randomized, controlled, open-label, phase 2 trial (HCHTOG1906).

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Title: Sequential versus concurrent neoadjuvant immunochemotherapy in locally advanced esophageal squamous cell carcinoma: a randomized, controlled, open-label, phase 2 trial (HCHTOG1906).
Authors: Zheng Y; State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital, Zhengzhou, Henan, China., Wu J; Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital, Zhengzhou, Henan, China., Zhao L; Department of Immunotherapy, Cancer Hospital Affiliated to Zhengzhou University and Henan Cancer Hospital, , Zhengzhou, Henan, China., Shen Y; Department of Thoracic Surgery, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China., Liang G; Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital, Zhengzhou, Henan, China., Li K; Department of Thoracic Surgery, The Affiliated Chest Hospital of Zhengzhou University/Henan Chest Hospital, Zhengzhou, Henan, China., Gao Q; Department of Immunotherapy, Cancer Hospital Affiliated to Zhengzhou University and Henan Cancer Hospital, , Zhengzhou, Henan, China., Xing W; Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital, Zhengzhou, Henan, China.
Source: Frontiers in immunology [Front Immunol] 2026 May 07; Vol. 17, pp. 1770662. Date of Electronic Publication: 2026 May 07 (Print Publication: 2026).
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2026.1770662