Penfluridol directly targets PDPK1 to suppress AKT1 phosphorylation and stabilize CTR1, inducing cuproptosis in colorectal cancer.

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Title: Penfluridol directly targets PDPK1 to suppress AKT1 phosphorylation and stabilize CTR1, inducing cuproptosis in colorectal cancer.
Authors: Ni KM; School of Medicine, Nankai University, Tianjin, 300110, China., Wang HQ; School of Medicine, Nankai University, Tianjin, 300110, China., Shi XF; School of Medicine, Nankai University, Tianjin, 300110, China., Yu Q; Department of General Practice, Peking University Shenzhen Hospital, Shenzhen, 518036, China., Dai XT; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China., Wang JY; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China., Sun MM; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China., Yan Q; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China., Zhai XR; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China., Liu YF; School of Medicine, Nankai University, Tianjin, 300110, China., Zhao KL; School of Medicine, Nankai University, Tianjin, 300110, China., Wang WT; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China., Fu MW; Tianjin Medical University, Tianjin, 300203, China., Wang XT; School of Medicine, Nankai University, Tianjin, 300110, China., Fang SY; School of Medicine, Nankai University, Tianjin, 300110, China., Zhang J; School of Medicine, Nankai University, Tianjin, 300110, China., Wang HM; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China., Shan CL; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, 300350, China. changliangshan@nankai.edu.cn., Zhang S; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. shuaizhang@tjutcm.edu.cn., Zhang CZ; School of Medicine, Nankai University, Tianjin, 300110, China. chunze.zhang@nankai.edu.cn.; Department of Colorectal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China. chunze.zhang@nankai.edu.cn.; Tianjin Institute of Coloproctology, Tianjin, 300121, China. chunze.zhang@nankai.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 May 25. Date of Electronic Publication: 2026 May 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1745-7254
DOI:10.1038/s41401-026-01806-9