FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer's disease pathology.

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Title: FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer's disease pathology.
Authors: Zhang Y; Department of Neurology, Department of Urology, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China., Sun J; Department of Neurology, Department of Urology, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China., Cai Y; Department of Neurology, Department of Urology, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China., Xu Z; Department of Neurology, Department of Urology, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China., Li X; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China., Wei W; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China., Liu P; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Sun Q; Department of Respiratory and Critical Care Medicine, Center for Metabolism Research, Fourth Affiliated Hospital, Zhejiang University School of Medicine and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.; Departments of Biochemistry and Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Wang ZH; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.; Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China., Cui Y; Department of Neurology, Department of Urology, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China. yixian.cui@whu.edu.cn.
Source: The EMBO journal [EMBO J] 2026 May 26. Date of Electronic Publication: 2026 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1460-2075
DOI:10.1038/s44318-026-00818-9