Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations.

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Title: Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations.
Authors: Chang X; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Parkville, VIC, 3000, Australia. shirley.chang@unimelb.edu.au.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. shirley.chang@unimelb.edu.au.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, 119074, Singapore. shirley.chang@unimelb.edu.au., Li Z; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore., Thai PVK; Pham Ngoc Thach Hospital, District 5, Ho Chi Minh City, Viet Nam., Ha DTM; Pham Ngoc Thach Hospital, District 5, Ho Chi Minh City, Viet Nam., Thuong NTT; Oxford University Clinical Research Unit, District 5, Ho Chi Minh City, Viet Nam.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK., Wee D; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore., Subhan ASBM; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore., Silcocks M; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Parkville, VIC, 3000, Australia., Chee CBE; Tuberculosis Control Unit, Tan Tock Seng Hospital, Singapore, Singapore., Nhu NTQ; Oxford University Clinical Research Unit, District 5, Ho Chi Minh City, Viet Nam., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, 119074, Singapore., Teo YY; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Singhal A; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.; Department of Medicine, UMass Chan Medical School, Worcester, MA, 01605, United States of America.; Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore, 308232, Republic of Singapore., Oehlers SH; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore., Yuan JM; Cancer Epidemiology and Prevention Program, University of Pittsburgh Medical Centre (UPMC) Hillman Cancer Center, Pittsburgh, PA, 15232, USA.; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.; A*STAR Institute for Human Development and Potential, Singapore, Singapore., Caws M; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.; Birat Nepal Medical Trust, 257 Lazimpat, Kathmandu, Nepal., Khor CC; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.; Singapore Eye Research Institute, Singapore, Singapore., Dorajoo R; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore., Dunstan SJ; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Parkville, VIC, 3000, Australia. sarah.dunstan@unimelb.edu.au.
Source: Genome medicine [Genome Med] 2026 May 27; Vol. 18 (1). Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1756-994X
DOI:10.1186/s13073-026-01670-6