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Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations.

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Title: Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations.
Authors: Chang X; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Parkville, VIC, 3000, Australia. shirley.chang@unimelb.edu.au.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. shirley.chang@unimelb.edu.au.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, 119074, Singapore. shirley.chang@unimelb.edu.au., Li Z; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore., Thai PVK; Pham Ngoc Thach Hospital, District 5, Ho Chi Minh City, Viet Nam., Ha DTM; Pham Ngoc Thach Hospital, District 5, Ho Chi Minh City, Viet Nam., Thuong NTT; Oxford University Clinical Research Unit, District 5, Ho Chi Minh City, Viet Nam.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK., Wee D; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore., Subhan ASBM; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore., Silcocks M; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Parkville, VIC, 3000, Australia., Chee CBE; Tuberculosis Control Unit, Tan Tock Seng Hospital, Singapore, Singapore., Nhu NTQ; Oxford University Clinical Research Unit, District 5, Ho Chi Minh City, Viet Nam., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, 119074, Singapore., Teo YY; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Singhal A; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.; Department of Medicine, UMass Chan Medical School, Worcester, MA, 01605, United States of America.; Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore, 308232, Republic of Singapore., Oehlers SH; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore., Yuan JM; Cancer Epidemiology and Prevention Program, University of Pittsburgh Medical Centre (UPMC) Hillman Cancer Center, Pittsburgh, PA, 15232, USA.; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.; A*STAR Institute for Human Development and Potential, Singapore, Singapore., Caws M; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.; Birat Nepal Medical Trust, 257 Lazimpat, Kathmandu, Nepal., Khor CC; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.; Singapore Eye Research Institute, Singapore, Singapore., Dorajoo R; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore., Dunstan SJ; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Parkville, VIC, 3000, Australia. sarah.dunstan@unimelb.edu.au.
Source: Genome medicine [Genome Med] 2026 May 27; Vol. 18 (1). Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
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  Data: Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations.
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  Data: <searchLink fieldCode="AU" term="%22Chang+X%22">Chang X</searchLink>; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Parkville, VIC, 3000, Australia. shirley.chang@unimelb.edu.au.; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. shirley.chang@unimelb.edu.au.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, 119074, Singapore. shirley.chang@unimelb.edu.au.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Thai+PVK%22">Thai PVK</searchLink>; Pham Ngoc Thach Hospital, District 5, Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Ha+DTM%22">Ha DTM</searchLink>; Pham Ngoc Thach Hospital, District 5, Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Thuong+NTT%22">Thuong NTT</searchLink>; Oxford University Clinical Research Unit, District 5, Ho Chi Minh City, Viet Nam.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Wee+D%22">Wee D</searchLink>; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.<br /><searchLink fieldCode="AU" term="%22Subhan+ASBM%22">Subhan ASBM</searchLink>; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.<br /><searchLink fieldCode="AU" term="%22Silcocks+M%22">Silcocks M</searchLink>; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Parkville, VIC, 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Chee+CBE%22">Chee CBE</searchLink>; Tuberculosis Control Unit, Tan Tock Seng Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Nhu+NTQ%22">Nhu NTQ</searchLink>; Oxford University Clinical Research Unit, District 5, Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Heng+CK%22">Heng CK</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Teo+YY%22">Teo YY</searchLink>; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Singhal+A%22">Singhal A</searchLink>; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.; Department of Medicine, UMass Chan Medical School, Worcester, MA, 01605, United States of America.; Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore, 308232, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Oehlers+SH%22">Oehlers SH</searchLink>; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.<br /><searchLink fieldCode="AU" term="%22Yuan+JM%22">Yuan JM</searchLink>; Cancer Epidemiology and Prevention Program, University of Pittsburgh Medical Centre (UPMC) Hillman Cancer Center, Pittsburgh, PA, 15232, USA.; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.<br /><searchLink fieldCode="AU" term="%22Koh+WP%22">Koh WP</searchLink>; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.; A*STAR Institute for Human Development and Potential, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Caws+M%22">Caws M</searchLink>; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.; Birat Nepal Medical Trust, 257 Lazimpat, Kathmandu, Nepal.<br /><searchLink fieldCode="AU" term="%22Khor+CC%22">Khor CC</searchLink>; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.; Singapore Eye Research Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Dorajoo+R%22">Dorajoo R</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Dunstan+SJ%22">Dunstan SJ</searchLink>; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Parkville, VIC, 3000, Australia. sarah.dunstan@unimelb.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101475844%22">Genome medicine</searchLink> [Genome Med] 2026 May 27; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 May 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101475844 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-994X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221756994X%22">1756994X </searchLink><i>NLM ISO Abbreviation: </i>Genome Med <i>Subsets: </i>MEDLINE
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