Blood Focused-Metabolomics and Transcriptomics Uncover Non-Linear Risk Association of Inadequate Dietary Choline Intake-Linked Metabolic Stress with MASLD Through Amino Acid Biomarkers, BCAA and MTORC 1/AKT1/IRS1 Mechanistic Mediators: A Nested Case-Control Study.
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| Title: | Blood Focused-Metabolomics and Transcriptomics Uncover Non-Linear Risk Association of Inadequate Dietary Choline Intake-Linked Metabolic Stress with MASLD Through Amino Acid Biomarkers, BCAA and MTORC 1/AKT1/IRS1 Mechanistic Mediators: A Nested Case-Control Study. |
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| Authors: | Wu CH; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Gastroenterology and Hepatology, Taipei Hospital, Ministry of Health and Welfare, New Taipei City 242033, Taiwan.; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan., Lin ML; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Biomedical Engineering, Dayeh University, Changhua City 51591, Taiwan., Wang CY; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan., Chang CY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City 242062, Taiwan., Lee FJ; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City 242062, Taiwan., Cheng ML; Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan., Lin YS; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Nutrition, China Medical University, Taichung City 406040, Taiwan., Chen TW; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan., Hsiao YT; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan., Wang BW; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Nutrition, Fu Jen Catholic University Hospital, New Taipei City 243089, Taiwan., Kuo CS; Department of Nutrition, Fu Jen Catholic University Hospital, New Taipei City 243089, Taiwan., Huang RS; Ph.D. Program in Nutrition and Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.; Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan. |
| Source: | International journal of molecular sciences [Int J Mol Sci] 2026 May 08; Vol. 27 (10). Date of Electronic Publication: 2026 May 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1422-0067 |
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| DOI: | 10.3390/ijms27104186 |
