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Interpretation of Pharmacometabolomics Results: Fingerprint of Drug Exposure or Confounder Effects? Insights from a Urinary Metabolomics Study with Voriconazole in Healthy Participants.

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Title: Interpretation of Pharmacometabolomics Results: Fingerprint of Drug Exposure or Confounder Effects? Insights from a Urinary Metabolomics Study with Voriconazole in Healthy Participants.
Authors: Chobanyan-Jürgens K; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Center for Pediatrics and Adolescent Medicine, Department of Pediatrics I, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Pediatric Clinical-Pharmacological Trial Center (paedKliPS), Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Muhareb A; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany., Niesert M; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Center for Pediatrics and Adolescent Medicine, Department of Pediatrics I, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Pediatric Clinical-Pharmacological Trial Center (paedKliPS), Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Scherkl C; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany., Meid AD; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany., Cannet C; Bruker BioSpin GmbH & Co. KG, 76275 Ettlingen, Germany., Pituk D; Bruker BioSpin GmbH & Co. KG, 76275 Ettlingen, Germany., Hoffmann GF; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Center for Pediatrics and Adolescent Medicine, Department of Pediatrics I, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Stingl JC; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany., Ziegler A; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Center for Pediatrics and Adolescent Medicine, Department of Pediatrics I, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Pediatric Clinical-Pharmacological Trial Center (paedKliPS), Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Blank A; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Source: International journal of molecular sciences [Int J Mol Sci] 2026 May 16; Vol. 27 (10). Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article; Clinical Trial
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Chobanyan-Jürgens+K%22">Chobanyan-Jürgens K</searchLink>; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Center for Pediatrics and Adolescent Medicine, Department of Pediatrics I, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Pediatric Clinical-Pharmacological Trial Center (paedKliPS), Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Muhareb+A%22">Muhareb A</searchLink>; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Niesert+M%22">Niesert M</searchLink>; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Center for Pediatrics and Adolescent Medicine, Department of Pediatrics I, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Pediatric Clinical-Pharmacological Trial Center (paedKliPS), Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Scherkl+C%22">Scherkl C</searchLink>; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Meid+AD%22">Meid AD</searchLink>; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Cannet+C%22">Cannet C</searchLink>; Bruker BioSpin GmbH & Co. KG, 76275 Ettlingen, Germany.<br /><searchLink fieldCode="AU" term="%22Pituk+D%22">Pituk D</searchLink>; Bruker BioSpin GmbH & Co. KG, 76275 Ettlingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+GF%22">Hoffmann GF</searchLink>; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Center for Pediatrics and Adolescent Medicine, Department of Pediatrics I, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stingl+JC%22">Stingl JC</searchLink>; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ziegler+A%22">Ziegler A</searchLink>; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Center for Pediatrics and Adolescent Medicine, Department of Pediatrics I, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Pediatric Clinical-Pharmacological Trial Center (paedKliPS), Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Blank+A%22">Blank A</searchLink>; Heidelberg University, Medical Faculty Heidelberg, Heidelberg University Hospital, Internal Medicine IX-Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
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              Text: 2026 May 16
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