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The PET tracer [11C]MODAG-005 targets alpha-synuclein aggregates in the brain.

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Title: The PET tracer [11C]MODAG-005 targets alpha-synuclein aggregates in the brain.
Authors: Saw RS; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany., Haas S; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany., Schmidt F; MODAG GmbH, 55234 Wendelsheim, Germany., Ryazanov S; MODAG GmbH, 55234 Wendelsheim, Germany.; Department of NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, 37077 Goettingen, Germany., Leonov A; MODAG GmbH, 55234 Wendelsheim, Germany.; Department of NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, 37077 Goettingen, Germany., Bleher D; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany., Grotegerd AK; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany., Kuebler L; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany., Roeben B; Department of Neurology, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany., Schmidt F; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany.; Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University Hospital Tuebingen, 72076 Tuebingen, Germany., Reimold M; Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University Hospital Tuebingen, 72076 Tuebingen, Germany., Bonanno F; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany., Ruf VC; Ludwig Maximilians University, Center for Neuropathology and Prion Research, 81377 Munich, Germany., Dahl B; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany.; Graduate School of Cellular and Molecular Neuroscience, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany., Sandiego CM; Invicro LLC, Needham, MA 02494, USA., Henry KE; Invicro LLC, Needham, MA 02494, USA., Papadopoulos I; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany., Schaller M; Department of Dermatology, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany., Kahle PJ; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany., Levin J; MODAG GmbH, 55234 Wendelsheim, Germany.; Department of Neurology, Ludwig-Maximilians-University Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), site Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Gasser T; Department of Neurology, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany., Brockmann K; Department of Neurology, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.; Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany.; German Center for Neurodegenerative Diseases, 72076 Tuebingen, Germany., Reischl G; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany., la Fougère C; Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University Hospital Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany., Pichler BJ; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany., Maurer A; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany., Griesinger C; Department of NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, 37077 Goettingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells' (MBExC), University of Goettingen; 37075 Goettingen, Germany., Giese A; MODAG GmbH, 55234 Wendelsheim, Germany., Herfert K; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, 72076 Tuebingen, Germany.
Source: Science translational medicine [Sci Transl Med] 2026 May 27; Vol. 18 (851), pp. eaec0813. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.aec0813