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Mitochondrial NADH-redox inflexibility constrains genomic and epigenetic stability in pluripotent stem cells.

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Title: Mitochondrial NADH-redox inflexibility constrains genomic and epigenetic stability in pluripotent stem cells.
Authors: Ahmed T; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China. tahmed@bs.qau.edu.pk.; Cadson College of Pharmacy, University of the Punjab, Lahore, Pakistan. tahmed@bs.qau.edu.pk., Zhang H; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), 510005, Guangzhou, China., Mushraf GM; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Pan Y; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Zhang Z; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Sun Z; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Yin M; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Xu X; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Wu X; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.; Medical Science Program, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand., Gao Y; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.; Medical Science Program, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand., Li Y; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, China., Li P; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Ding L; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Zhang Q; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Lin R; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Ullah K; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Huang Y; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Mirza B; Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan., Huang Y; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Sammad A; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Kong X; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China., Qin D; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, China., Esteban MA; The Fifth Affiliated Hospital of Guangzhou Medical University-BGI Center for Integrative Biology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.; 3DC STAR Lab, BGI CELL, Shenzhen, 518083, China.; Prince Fahad bin Sultan Research Chair for Biomedical Research, University of Tabuk, Tabuk, 47713, Saudi Arabia., Wang L; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, China. wang_lulu@gzhmu.edu.cn., Qin B; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China. qin_baoming@gibh.ac.cn.; The Fifth Affiliated Hospital of Guangzhou Medical University-BGI Center for Integrative Biology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China. qin_baoming@gibh.ac.cn.; 3DC STAR Lab, BGI CELL, Shenzhen, 518083, China. qin_baoming@gibh.ac.cn.
Source: The EMBO journal [EMBO J] 2026 Jul; Vol. 45 (13), pp. 4417-4446. Date of Electronic Publication: 2026 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mitochondrial NADH-redox inflexibility constrains genomic and epigenetic stability in pluripotent stem cells.
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  Data: <searchLink fieldCode="AU" term="%22Ahmed+T%22">Ahmed T</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China. tahmed@bs.qau.edu.pk.; Cadson College of Pharmacy, University of the Punjab, Lahore, Pakistan. tahmed@bs.qau.edu.pk.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), 510005, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Mushraf+GM%22">Mushraf GM</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Pan+Y%22">Pan Y</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Sun+Z%22">Sun Z</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Yin+M%22">Yin M</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.; Medical Science Program, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.; Medical Science Program, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, China.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Ding+L%22">Ding L</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Lin+R%22">Lin R</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Ullah+K%22">Ullah K</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Mirza+B%22">Mirza B</searchLink>; Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Sammad+A%22">Sammad A</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Kong+X%22">Kong X</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China.<br /><searchLink fieldCode="AU" term="%22Qin+D%22">Qin D</searchLink>; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, China.<br /><searchLink fieldCode="AU" term="%22Esteban+MA%22">Esteban MA</searchLink>; The Fifth Affiliated Hospital of Guangzhou Medical University-BGI Center for Integrative Biology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.; 3DC STAR Lab, BGI CELL, Shenzhen, 518083, China.; Prince Fahad bin Sultan Research Chair for Biomedical Research, University of Tabuk, Tabuk, 47713, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, China. wang_lulu@gzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Qin+B%22">Qin B</searchLink>; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, 510530, China. qin_baoming@gibh.ac.cn.; The Fifth Affiliated Hospital of Guangzhou Medical University-BGI Center for Integrative Biology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China. qin_baoming@gibh.ac.cn.; 3DC STAR Lab, BGI CELL, Shenzhen, 518083, China. qin_baoming@gibh.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Jul; Vol. 45 (13), pp. 4417-4446. <i>Date of Electronic Publication: </i>2026 May 27.
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