Targeting epigenetic and DNA topology mechanisms: histone deacetylases and topoisomerase inhibitors in combination and dual inhibition approaches.

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Title: Targeting epigenetic and DNA topology mechanisms: histone deacetylases and topoisomerase inhibitors in combination and dual inhibition approaches.
Authors: Reddy Y; Department of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India., Bhat VG; Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India., Kumar MV; Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India., Das I; Department of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India., Sundara BK; Department of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. babitha.ks@manipal.edu.
Source: Pharmacological reports : PR [Pharmacol Rep] 2026 May 28. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101234999 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2299-5684 (Electronic) Linking ISSN: 17341140 NLM ISO Abbreviation: Pharmacol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2299-5684
DOI:10.1007/s43440-026-00868-0