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AI-based histopathology analysis predicts checkpoint inhibitor response in advanced melanoma and identifies patterns associated with response.

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Title: AI-based histopathology analysis predicts checkpoint inhibitor response in advanced melanoma and identifies patterns associated with response.
Authors: Schuiveling M; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands. Electronic address: m.schuiveling@umcutrecht.nl., van Duin IAJ; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands., Ter Maat LS; Image Sciences Institute, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands., van der Weerd JC; Department of Pathology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, the Netherlands., Verheijden RJ; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands., van den Berkmortel F; Department of Medical Oncology, Zuyderland Medical Center Sittard, Dr. H. van der Hoffplein 1, Sittard-Geleen 6162 BG, the Netherlands., Blank CU; Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066CX, the Netherlands., Breimer GE; Department of Pathology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands., Burgers FH; Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066CX, the Netherlands., Boers-Sonderen M; Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 10, Nijmegen 6525 GA, the Netherlands., Labots M; Department of Medical Oncology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1118, Amsterdam 1081 Hz, the Netherlands., de Groot JWB; Isala Oncology Center, Isala, Dokter van Heesweg 2, Zwolle 8025 AB, the Netherlands., Haanen JBAG; Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066CX, the Netherlands; Department of Medical Oncology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333ZA, the Netherlands; Division of Molecular Oncology and Immunology, Oncode Institute, Amsterdam 1066 CX, the Netherlands; Melanoma Clinic, Center Hospitalier Universitaire Vaudois, Lausanne 1005, Switzerland., Hospers GAP; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, the Netherlands., Kapiteijn E; Department of Medical Oncology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333ZA, the Netherlands., Piersma D; Department of Internal Medicine, Medisch Spectrum Twente, Koningsplein 1, Enschede 7512 KZ, the Netherlands., Simkens L; Department of Internal Medicine, Maxima Medical Center, De Run 4600, Eindhoven 5504 DB, the Netherlands., Westgeest HM; Department of Internal Medicine, Amphia Hospital, Molengracht 21, Breda 4818 CK, the Netherlands., Schrader AMR; Department of Pathology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, the Netherlands., Pluim JPW; Medical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, the Netherlands., van Diest PJ; Department of Pathology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands., Blokx WAM; Department of Pathology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands., Veta M; Medical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, the Netherlands., Suijkerbuijk KPM; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Jun 25; Vol. 242, pp. 116831. Date of Electronic Publication: 2026 May 25.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: AI-based histopathology analysis predicts checkpoint inhibitor response in advanced melanoma and identifies patterns associated with response.
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  Data: <searchLink fieldCode="AU" term="%22Schuiveling+M%22">Schuiveling M</searchLink>; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands. Electronic address: m.schuiveling@umcutrecht.nl.<br /><searchLink fieldCode="AU" term="%22van+Duin+IAJ%22">van Duin IAJ</searchLink>; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ter+Maat+LS%22">Ter Maat LS</searchLink>; Image Sciences Institute, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Weerd+JC%22">van der Weerd JC</searchLink>; Department of Pathology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verheijden+RJ%22">Verheijden RJ</searchLink>; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Berkmortel+F%22">van den Berkmortel F</searchLink>; Department of Medical Oncology, Zuyderland Medical Center Sittard, Dr. H. van der Hoffplein 1, Sittard-Geleen 6162 BG, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Blank+CU%22">Blank CU</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066CX, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Breimer+GE%22">Breimer GE</searchLink>; Department of Pathology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Burgers+FH%22">Burgers FH</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066CX, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Boers-Sonderen+M%22">Boers-Sonderen M</searchLink>; Department of Medical Oncology, Radboud University Medical Center, Geert Grooteplein Zuid 10, Nijmegen 6525 GA, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Labots+M%22">Labots M</searchLink>; Department of Medical Oncology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1118, Amsterdam 1081 Hz, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Groot+JWB%22">de Groot JWB</searchLink>; Isala Oncology Center, Isala, Dokter van Heesweg 2, Zwolle 8025 AB, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Haanen+JBAG%22">Haanen JBAG</searchLink>; Department of Medical Oncology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066CX, the Netherlands; Department of Medical Oncology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333ZA, the Netherlands; Division of Molecular Oncology and Immunology, Oncode Institute, Amsterdam 1066 CX, the Netherlands; Melanoma Clinic, Center Hospitalier Universitaire Vaudois, Lausanne 1005, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hospers+GAP%22">Hospers GAP</searchLink>; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kapiteijn+E%22">Kapiteijn E</searchLink>; Department of Medical Oncology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333ZA, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Piersma+D%22">Piersma D</searchLink>; Department of Internal Medicine, Medisch Spectrum Twente, Koningsplein 1, Enschede 7512 KZ, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Simkens+L%22">Simkens L</searchLink>; Department of Internal Medicine, Maxima Medical Center, De Run 4600, Eindhoven 5504 DB, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Westgeest+HM%22">Westgeest HM</searchLink>; Department of Internal Medicine, Amphia Hospital, Molengracht 21, Breda 4818 CK, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schrader+AMR%22">Schrader AMR</searchLink>; Department of Pathology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pluim+JPW%22">Pluim JPW</searchLink>; Medical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Diest+PJ%22">van Diest PJ</searchLink>; Department of Pathology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Blokx+WAM%22">Blokx WAM</searchLink>; Department of Pathology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Veta+M%22">Veta M</searchLink>; Medical Image Analysis, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, Eindhoven 5600 MB, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Suijkerbuijk+KPM%22">Suijkerbuijk KPM</searchLink>; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CG, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 Jun 25; Vol. 242, pp. 116831. <i>Date of Electronic Publication: </i>2026 May 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9005373 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0852 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209598049%22">09598049 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Cancer <i>Subsets: </i>MEDLINE
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