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Efficacy of dual KRASG12D-EGFR blockade versus triple combinations in patient-derived models of KRASG12D-mutant colorectal cancer.

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Title: Efficacy of dual KRASG12D-EGFR blockade versus triple combinations in patient-derived models of KRASG12D-mutant colorectal cancer.
Authors: Leto SM; Candiolo Cancer Institute-FPO IRCCS, 10060, Candiolo, Torino, Italy., Sassi F; Candiolo Cancer Institute-FPO IRCCS, 10060, Candiolo, Torino, Italy., Zanella ER; Candiolo Cancer Institute-FPO IRCCS, 10060, Candiolo, Torino, Italy., Vurchio V; Candiolo Cancer Institute-FPO IRCCS, 10060, Candiolo, Torino, Italy.; Department of Oncology, Candiolo Satellite, University of Torino, 10060, Candiolo, Torino, Italy., Cottino F; Candiolo Cancer Institute-FPO IRCCS, 10060, Candiolo, Torino, Italy., Ferri M; Candiolo Cancer Institute-FPO IRCCS, 10060, Candiolo, Torino, Italy., Damico A; Candiolo Cancer Institute-FPO IRCCS, 10060, Candiolo, Torino, Italy.; Department of Oncology, Candiolo Satellite, University of Torino, 10060, Candiolo, Torino, Italy., Grassi E; Candiolo Cancer Institute-FPO IRCCS, 10060, Candiolo, Torino, Italy.; Department of Oncology, Candiolo Satellite, University of Torino, 10060, Candiolo, Torino, Italy., Bertotti A; Candiolo Cancer Institute-FPO IRCCS, 10060, Candiolo, Torino, Italy. andrea.bertotti@ircc.it.; Department of Oncology, Candiolo Satellite, University of Torino, 10060, Candiolo, Torino, Italy. andrea.bertotti@ircc.it., Trusolino L; Candiolo Cancer Institute-FPO IRCCS, 10060, Candiolo, Torino, Italy. livio.trusolino@ircc.it.; Department of Oncology, Candiolo Satellite, University of Torino, 10060, Candiolo, Torino, Italy. livio.trusolino@ircc.it.
Source: Cell death & disease [Cell Death Dis] 2026 May 28. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-4889
DOI:10.1038/s41419-026-08900-0