VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS.

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Title: VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS.
Authors: Tripathi P; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.; EURON - European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands., Guo H; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany., Yamoah A; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.; EURON - European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands., Mathur R; Department of Geriatrics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58202, USA., Doukas P; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany., Dreser A; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany., Jesse CM; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.; Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Aronica E; Amsterdam UMC, Department of (Neuro) Pathology, Amsterdam Neuroscience, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands., Hermann A; Translational Neurodegeneration Section 'Albrecht Kossel', Department of Neurology and Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, 18147, Rostock, Germany.; German Centre for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, 18147, Rostock, Germany., Steinbusch H; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; EURON - European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands., Brook GA; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany., Weis J; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany. jweis@ukaachen.de., Goswami A; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany. ag4755@cumc.columbia.edu.; Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY, USA. ag4755@cumc.columbia.edu.; Department of Neurology, Eleanor and Lou Gehrig ALS Center, Columbia University, New York, NY, USA. ag4755@cumc.columbia.edu.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 May 29; Vol. 14 (1). Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-5960
DOI:10.1186/s40478-026-02298-8