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VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS.

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Title: VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS.
Authors: Tripathi P; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.; EURON - European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands., Guo H; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany., Yamoah A; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.; EURON - European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands., Mathur R; Department of Geriatrics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58202, USA., Doukas P; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany., Dreser A; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany., Jesse CM; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.; Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Aronica E; Amsterdam UMC, Department of (Neuro) Pathology, Amsterdam Neuroscience, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands., Hermann A; Translational Neurodegeneration Section 'Albrecht Kossel', Department of Neurology and Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, 18147, Rostock, Germany.; German Centre for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, 18147, Rostock, Germany., Steinbusch H; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; EURON - European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands., Brook GA; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany., Weis J; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany. jweis@ukaachen.de., Goswami A; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany. ag4755@cumc.columbia.edu.; Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY, USA. ag4755@cumc.columbia.edu.; Department of Neurology, Eleanor and Lou Gehrig ALS Center, Columbia University, New York, NY, USA. ag4755@cumc.columbia.edu.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 May 29; Vol. 14 (1). Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS.
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  Data: <searchLink fieldCode="AU" term="%22Tripathi+P%22">Tripathi P</searchLink>; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.; EURON - European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Guo+H%22">Guo H</searchLink>; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Yamoah+A%22">Yamoah A</searchLink>; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.; EURON - European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mathur+R%22">Mathur R</searchLink>; Department of Geriatrics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58202, USA.<br /><searchLink fieldCode="AU" term="%22Doukas+P%22">Doukas P</searchLink>; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Dreser+A%22">Dreser A</searchLink>; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Jesse+CM%22">Jesse CM</searchLink>; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.; Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Aronica+E%22">Aronica E</searchLink>; Amsterdam UMC, Department of (Neuro) Pathology, Amsterdam Neuroscience, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hermann+A%22">Hermann A</searchLink>; Translational Neurodegeneration Section 'Albrecht Kossel', Department of Neurology and Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, 18147, Rostock, Germany.; German Centre for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, 18147, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Steinbusch+H%22">Steinbusch H</searchLink>; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.; EURON - European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Brook+GA%22">Brook GA</searchLink>; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Weis+J%22">Weis J</searchLink>; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany. jweis@ukaachen.de.<br /><searchLink fieldCode="AU" term="%22Goswami+A%22">Goswami A</searchLink>; Institute of Neuropathology, RWTH Aachen University Hospital, Pauwelsstr. 30, 52074, Aachen, Germany. ag4755@cumc.columbia.edu.; Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY, USA. ag4755@cumc.columbia.edu.; Department of Neurology, Eleanor and Lou Gehrig ALS Center, Columbia University, New York, NY, USA. ag4755@cumc.columbia.edu.
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  Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2026 May 29; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 May 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101610673 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-5960 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220515960%22">20515960 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol Commun <i>Subsets: </i>MEDLINE
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