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Fluorinated Ultralong-Acting Neuromuscular Blocking Agent with Improved Activity Profile and Biosafety for the Development of Blockade and Reversal Partner Drugs.

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Title: Fluorinated Ultralong-Acting Neuromuscular Blocking Agent with Improved Activity Profile and Biosafety for the Development of Blockade and Reversal Partner Drugs.
Authors: Gan SX; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China., Zhang RL; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China., Guo C; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China., Qi QY; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China., Feng K; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China., Yu SB; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China., Wang H; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China., Zhou W; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China., Zhao G; School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen 518055, China.; Shinewin Pharmaceuticals, 108 Yuxin Road, Suzhou, Jiangsu 215123, China., Zhang DW; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China., Li ZT; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China.; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Jun 11; Vol. 69 (11), pp. 13966-13979. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fluorinated Ultralong-Acting Neuromuscular Blocking Agent with Improved Activity Profile and Biosafety for the Development of Blockade and Reversal Partner Drugs.
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  Data: <searchLink fieldCode="AU" term="%22Gan+SX%22">Gan SX</searchLink>; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Zhang+RL%22">Zhang RL</searchLink>; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Guo+C%22">Guo C</searchLink>; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Qi+QY%22">Qi QY</searchLink>; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Feng+K%22">Feng K</searchLink>; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Yu+SB%22">Yu SB</searchLink>; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Zhao+G%22">Zhao G</searchLink>; School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen 518055, China.; Shinewin Pharmaceuticals, 108 Yuxin Road, Suzhou, Jiangsu 215123, China.<br /><searchLink fieldCode="AU" term="%22Zhang+DW%22">Zhang DW</searchLink>; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China.<br /><searchLink fieldCode="AU" term="%22Li+ZT%22">Li ZT</searchLink>; Department of Chemistry, Fudan University, 2205 Songhu Road, Shanghai 200438, China.; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Jun 11; Vol. 69 (11), pp. 13966-13979. <i>Date of Electronic Publication: </i>2026 May 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42212455
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      – Type: doi
        Value: 10.1021/acs.jmedchem.6c01353
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        Text: English
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        StartPage: 13966
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      – TitleFull: Fluorinated Ultralong-Acting Neuromuscular Blocking Agent with Improved Activity Profile and Biosafety for the Development of Blockade and Reversal Partner Drugs.
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            – D: 11
              M: 06
              Text: 2026 Jun 11
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              Y: 2026
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